A 45-year-old man noticed multiple pinpoint red spots and bruises on his arms and legs. The hematologist confirmed the presence of petechiae, purpura, and ecchymoses on his extremities and ordered a complete blood count, prothrombin time, and partial thromboplastin time. The platelet count was 40 x 109/L, the mean platelet volume was 12.2 fL, and the diameter of platelets on the Wright-stained peripheral blood film appeared to exceed 6 mm. Other complete blood count parameters and the coagulation parameters were within normal limits. A Wright-stained bone marrow aspirate smear revealed 10 to 12 small unlobulated megakaryocytes per low-power microscopic field. Is the thrombocytopenia the result of inadequate bone marrow production? Explain why. Do these signs and symptoms indicate systemic (mucocutaneous) or anatomical (soft tissue) bleeding? Why?
A 45-year-old man noticed multiple pinpoint red spots and bruises on his arms and legs. The hematologist confirmed the presence of petechiae, purpura, and ecchymoses on his extremities and ordered a complete blood count, prothrombin time, and partial thromboplastin time. The platelet count was 40 x 109/L, the mean platelet volume was 12.2 fL, and the diameter of platelets on the Wright-stained peripheral blood film appeared to exceed 6 mm. Other complete blood count parameters and the coagulation parameters were within normal limits. A Wright-stained bone marrow aspirate smear revealed 10 to 12 small unlobulated megakaryocytes per low-power microscopic field. Is the thrombocytopenia the result of inadequate bone marrow production? Explain why. Do these signs and symptoms indicate systemic (mucocutaneous) or anatomical (soft tissue) bleeding? Why?
Chapter8: Have A Heart
Section: Chapter Questions
Problem 1M
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A 45-year-old man noticed multiple pinpoint red spots and bruises on his arms and legs. The hematologist confirmed the presence of petechiae, purpura, and ecchymoses on his extremities and ordered a complete blood count, prothrombin time, and partial thromboplastin time. The platelet count was 40 x 109/L, the mean platelet volume was 12.2 fL, and the diameter of platelets on the Wright-stained peripheral blood film appeared to exceed 6 mm. Other complete blood count parameters and the coagulation parameters were within normal limits. A Wright-stained bone marrow aspirate smear revealed 10 to 12 small unlobulated megakaryocytes per low-power microscopic field.
- Is the thrombocytopenia the result of inadequate bone marrow production? Explain why.
- Do these signs and symptoms indicate systemic (mucocutaneous) or anatomical (soft tissue) bleeding? Why?
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