48. A 58-year-old woman comes to the office because of a 1-month history of fatigue, fever, shortness of breath, and joint pain; she also has had a 3.2-kg (7-lb) weight loss during this period. Her temperature is 37.6°C (99.7°F), and respirations are 34/min. Physical examination shows tenderness to palpation over the maxillary sinus, nasal ulcerations, and a bulging, red left tympanic membrane. Laboratory studies show: Erythrocyte sedimentation rate Serum C-reactive protein 65 mm/h 8.2 mg/L (N=0.08-3.1) 2+ 2+ Urine Blood Protein Histologic examination of a biopsy specimen of affected lung tissue shows granulomata and vasculitis. An autoantibody is most likely directly binding which of the following cell types in this patient? OA) Basophils B) Endothelial cells C) Fibroblasts D) Neutrophils E) Plasma cells

Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
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48. A 58-year-old woman comes to the office because of a 1-month history of fatigue, fever, shortness of breath, and joint pain; she also
has had a 3.2-kg (7-lb) weight loss during this period. Her temperature is 37.6°C (99.7°F), and respirations are 34/min. Physical
examination shows tenderness to palpation over the maxillary sinus, nasal ulcerations, and a bulging, red left tympanic membrane.
Laboratory studies show:
Erythrocyte sedimentation rate
Serum C-reactive protein
65 mm/h
8.2 mg/L (N=0.08-3.1)
2+
2+
Urine
Blood
Protein
Histologic examination of a biopsy specimen of affected lung tissue shows granulomata and vasculitis. An autoantibody is most likely
directly binding which of the following cell types in this patient?
OA) Basophils
B) Endothelial cells
C) Fibroblasts
D) Neutrophils
E) Plasma cells
Transcribed Image Text:48. A 58-year-old woman comes to the office because of a 1-month history of fatigue, fever, shortness of breath, and joint pain; she also has had a 3.2-kg (7-lb) weight loss during this period. Her temperature is 37.6°C (99.7°F), and respirations are 34/min. Physical examination shows tenderness to palpation over the maxillary sinus, nasal ulcerations, and a bulging, red left tympanic membrane. Laboratory studies show: Erythrocyte sedimentation rate Serum C-reactive protein 65 mm/h 8.2 mg/L (N=0.08-3.1) 2+ 2+ Urine Blood Protein Histologic examination of a biopsy specimen of affected lung tissue shows granulomata and vasculitis. An autoantibody is most likely directly binding which of the following cell types in this patient? OA) Basophils B) Endothelial cells C) Fibroblasts D) Neutrophils E) Plasma cells
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