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- Following is the structure of miconazole, the active antifungal agent in a number of over-the-counter preparations, including Monistat, that are used to treat vaginal yeast infections. One of the compounds needed for the synthesis of miconazole is the trichloro derivative of toluene shown on its right. (a) Show how this derivative can be synthesized from toluene. (b) How many stereoisomers are possible for miconazole?(R)-Pulegone, readily available from pennyroyal oil, is an important enantiopure building block for organic syntheses. Propose a mechanism for each step in this transformation of pulegone.What reagents are necessary to carry out the conversion shown? O OCH3CH₂ONa; H₂O OCH3CH₂MgBr; H₂O HO OCH3CH₂CH₂ONA; H₂O OCH3CH₂CH₂MgBr; H₂O
- Propose a mechanism for each of the following reaction. (i) CH2-SMe2 Ph3 B PHCH2OH (ii) H2O2/ NaOHWhich reagents can be used to achieve synthesis of the indicated target molecule? Conc. KMNO4/ H* / acetone 1) O3/ Zn/H* 2) PCC/CH2Cl2 O 1) Conc. KMNO4 /H* 2) LIAIH4/THF 4) H3O* 1) Conc. KMNO4, 2) HBr, 3) Mg/ether, 4) CO2 O3/ Zn/H*Provide a mechanism for the following transformation. кон, А
- please provide a reagent and detailed mechanism with arrows intermediates charges and lone pairs ame- NCO NH2 COOH GabapentinDevise a synthetic strategy to complete the following transformation. Ian - CO₂H H₂N N. CO₂HThe alkaline hydrolysis of the following compound yields: CH3-C-N(CH₂CH3)2 CH3C00+ NH3 + CH3CH2OH CH3COOH + (CH3CH2)2N-OH CH3COOH + (CH3CH2)2NH O CH3C00+ (CH3CH2)2NH