Genetics: Analysis and Principles
6th Edition
ISBN: 9781259616020
Author: Robert J. Brooker Professor Dr.
Publisher: McGraw-Hill Education
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Chapter 17.5, Problem 1COMQ
Which of the following components are needed for the adaptation phase of the CRISPR-Cas system?
a. crRNA and Cas1
b. crRNA and Cas2
c. crRNA and Cas9
d. Cas1 and Cas2
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Students have asked these similar questions
In the CRISPR-Cas system, what does the tracrRNA bind to?a. crRNA and Cas1b. crRNA and Cas2c. crRNA and Cas9d. Cas1 and Cas2
Using CRISPR/Cas9 to target a gene in the mouse will primarily result in:
a. Any of the choices
b. Synonymous substitutions
C. Homozygous gene knockouts
d.
Missense mutations
e. Frameshift mutations
1. a. CRISPR-Cas9 is a valuable biotechnology tool. Explain how this system uses RNA and the result of the interaction.
b. How is this different from miRNA?
Chapter 17 Solutions
Genetics: Analysis and Principles
Ch. 17.1 - Which of the following can bind to ncRNAs? a. DNA...Ch. 17.1 - 2. When an ncRNA functions as a decoy, it
a....Ch. 17.1 - Prob. 3COMQCh. 17.2 - 1. Which of the following functions does HOTAIR...Ch. 17.3 - 1. The process of RNA interference may lead to
a....Ch. 17.3 - 2. In catalyzing the methylation or...Ch. 17.4 - 1. Which of the following is a function of SRP?...Ch. 17.5 - 1. Which of the following components are needed...Ch. 17.5 - 2. In the CRISPR-Cas system, what does the...Ch. 17.5 - Which of the following is a function of the...
Ch. 17.6 - Prob. 1COMQCh. 17.6 - Let's suppose that the overexpression of a...Ch. 17 - 1. List and briefly describe four types of...Ch. 17 - 2. An ncRNA may have the following functions:...Ch. 17 - 3. What is meant by the term RNA world? Describe...Ch. 17 - Explain how HOTAIR plays a role in the...Ch. 17 - What is the phenomenon of RNA interference (RNAi)?...Ch. 17 - With regard to RNAi, what are three possible...Ch. 17 - 7. What is the difference between an miRNA and an...Ch. 17 - Together with a specific set of proteins, snoRNAs...Ch. 17 - Describe the structure of SRP in eukaryotes, and...Ch. 17 - Look at Figure 17.6 and predict what would happen...Ch. 17 - Compare and contrast the roles of crRNA and...Ch. 17 - In the CRISPR-Cas system, does the tracrRNA act as...Ch. 17 - Prob. 13CONQCh. 17 - Outline the steps that occur when piRISCs silence...Ch. 17 - List five types of cancer in which ncRNAs can be...Ch. 17 - Prob. 16CONQCh. 17 - A protein called trypsin, which plays a role in...Ch. 17 - Prob. 2EQCh. 17 - Prob. 3EQCh. 17 - As described in Chapter 21, the CRISPR-Cas system...Ch. 17 - Prob. 5EQCh. 17 - Prob. 6EQCh. 17 - Prob. 1QSDCCh. 17 - Go to the PubMed website and do a search using the...
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- Which of these statements is correct regarding the CRISPR/Cas9 system in eukaryotic cells? a.Single guide RNA (sgRNA) is used to target specific DNA sequences and activate Cas. b.Bacteriophages are used to inject viral genes into the cell to activated the Cas protein. c.CRISPR takes advantage of the cell’s DNA polymerase proof-reading activities for DNA replication errors d.The CRISPR-Cas system can only be used to alter genomes in prokaryotic cells. e.Cas cuts directly into palindromic restriction sites that it targets in the DNA.arrow_forwardWhich of these statements is correct regarding the CRISPR/Cas9 system in eukaryotic cells? A.Single guide RNA (sgRNA) is used to target specific DNA sequences and activate Cas. B.Bacteriophages are used to inject viral genes into the cell to activated the Cas protein. C.CRISPR takes advantage of the cell’s DNA polymerase proof-reading activities for DNA replication errors D.The CRISPR-Cas system can only be used to alter genomes in prokaryotic cells. E. Cas cuts directly into palindromic restriction sites that it targets in the DNA.arrow_forwardDescribe the following a. Core enzyme RNA polymerase b. Sigma factor c. Promoter consensus sequence d. Rho Dependent Factor e. Intrinsic Factor f. Abortive Initiationarrow_forward
- Based on recent data arising from various animal models, which of the following CRISPR-Cas9 systems would be the most promising to treat anxiety in humans? O A. CRISPR-dCas9 alone. O B. CRISPR-nCas9 fused with DNMT3A C. CRISPR-dCas9 fused with histone acetyltransferase. O D. CRISPR-nCas9 fused with deaminase and UGI. Reset Selectionarrow_forwardIdentification and quantification of expressed genes initially requires a. reverse transcription of mRNA to cDNA b. fragmentation of the whole genome c. ligation to adapters of known sequences d. ligation of a target gene to a vectorarrow_forwardDefine the following terms:a. signal peptideb. preinitiation complexc. initiation complexd. PABPe. cap-binding complexarrow_forward
- Diagram the mechanism by which CRISPR-cas functions in the immune system of bacteria.arrow_forwardChoose the item in column 2 that best matches each item in column 1. A. Provides information for production of protein B. Binds to promoter C. Promoter has a box A and box B consensus sequences D. Autocatalytic RNA molecules E. Associated with transcription termination F. Polymerization of ribonucleotides to form RNA molecules G. 7-methyl guanosine H. MRNA prior to processing select - 1. Core RNA polymerase select 2. rho (p) factor select 3. hnRNA select - 4. RNA select -5. RNA polymerase holoenzyme select 6. Ribozymes select - 7. 5' MRNA cap select 8. MRNAarrow_forwardDescribe the three steps of CRISPR-Cas–mediated antiviral defense.arrow_forward
- Which of the following types of transposable elements rely onan RNA intermediate for transposition?a. Insertion elementsb. Simple transposonsc. Retrotransposonsd. All of the abovearrow_forwardOutline the three stages of CRISPR-Cas action.arrow_forwardExplain How Single-nucleotide mutations can be introduced into the genome using an engineered CRISPR-Cas9 system.arrow_forward
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