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yruvate carboxylase catalyzes the first step of gluconeogenesis.   ATP + HCO3─ +  pyruvate  →   oxaloacetate + ADP + Pi   ∆G0’ = ─2.1 kJ mol-1   a) Calculate ΔG for this reaction under the following physiological conditions: 370C, pH 7      [pyruvate] = [HCO3─] = 4.0 mM      [oxaloacetate]= 2.0 mM      [ATP] = 3.5 mM      [Pi] = 5.0 mM      [ADP] = 1.8 mM

yruvate carboxylase catalyzes the first step of gluconeogenesis.   ATP + HCO3─ +  pyruvate  →   oxaloacetate + ADP + Pi   ∆G0’ = ─2.1 kJ mol-1   a) Calculate ΔG for this reaction under the following physiological conditions: 370C, pH 7      [pyruvate] = [HCO3─] = 4.0 mM      [oxaloacetate]= 2.0 mM      [ATP] = 3.5 mM      [Pi] = 5.0 mM      [ADP] = 1.8 mM

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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Pyruvate carboxylase catalyzes the first step of gluconeogenesis.

 

ATP + HCO3─ +  pyruvate  →   oxaloacetate + ADP + Pi   ∆G0’ = ─2.1 kJ mol-1

 

a) Calculate ΔG for this reaction under the following physiological conditions: 370C, pH 7

     [pyruvate] = [HCO3─] = 4.0 mM

     [oxaloacetate]= 2.0 mM

     [ATP] = 3.5 mM

     [Pi] = 5.0 mM

     [ADP] = 1.8 mM

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