Within living cells, many different proteins play importantfunctional roles by binding to DNA. Some proteins bind to DNA butnot in a sequence-specific manner. For example, histones are proteinsimportant in the formation of chromosome structure. The positivelycharged histone proteins bind to the negatively charged phosphategroups in DNA. In addition, several other proteins interact with DNAbut do not require a specific nucleotide sequence to carry out theirfunction. For example, DNA polymerase, which catalyzes thesynthesis of new DNA strands, does not bind to DNA in a sequencedependentmanner. By comparison, many other proteins do interactwith nucleic acids in a sequence-dependent fashion. This means thata specific sequence of bases can provide a structure that isrecognized by a particular protein.Someexamples include transcription factors that affect the rate oftranscription and proteins that bind to origins of replication inbacteria. With regard to the three-dimensional structure of DNA,where would you expect DNA-binding proteins to bind if theyrecognize a specific base sequence? What about DNA-bindingproteins that do not recognize a base sequence?
Within living cells, many different proteins play important
functional roles by binding to DNA. Some proteins bind to DNA but
not in a sequence-specific manner. For example, histones are proteins
important in the formation of chromosome structure. The positively
charged histone proteins bind to the negatively charged phosphate
groups in DNA. In addition, several other proteins interact with DNA
but do not require a specific
function. For example, DNA polymerase, which catalyzes the
synthesis of new DNA strands, does not bind to DNA in a sequencedependent
manner. By comparison, many other proteins do interact
with
a specific sequence of bases can provide a structure that is
recognized by a particular protein.Some
examples include transcription factors that affect the rate of
transcription and proteins that bind to origins of replication in
bacteria. With regard to the three-dimensional structure of DNA,
where would you expect DNA-binding proteins to bind if they
recognize a specific base sequence? What about DNA-binding
proteins that do not recognize a base sequence?
Within the living cells, various proteins play an important role in function by binding to the DNA. However, some proteins do not bind in a sequence-specific manner to the DNA. For example, histones play an important role in the formation of the chromosome’s structure. The histones that are positively charged binds to phosphate group that is negatively charged in the DNA. While some other protein interactions with the DNA do not need the specific sequence of the nucleotide to play their function. Many other proteins interact in a sequence-dependent manner with the nucleic acids. So, the specific sequence of the base may provide a structure which is recognized by the particular protein.
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