Why do you think antibodies against the N-terminal domain (NTD) provide protection against SARS-CoV2 when the NTD does not interact with the ACE2 receptor? Question 23 options: Binding causes steric hindrance of ACE2 to the receptor binding domain (RBD). Antibodies interact with antigens using a lock-and-key interaction Antibodies against the NTD recruit antibodies against the receptor binding domain (RBD). Antibodies against the NTD are not protective. Binding causes a conformational change in the RBD domain.

Why do you think antibodies against the N-terminal domain (NTD) provide protection against SARS-CoV2 when the NTD does not interact with the ACE2 receptor? Question 23 options: Binding causes steric hindrance of ACE2 to the receptor binding domain (RBD). Antibodies interact with antigens using a lock-and-key interaction Antibodies against the NTD recruit antibodies against the receptor binding domain (RBD). Antibodies against the NTD are not protective. Binding causes a conformational change in the RBD domain.

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Description: Why do you think antibodies against the N-terminal domain (NTD) provide protection against SARS-CoV2 when the NTD does not interact with the ACE2 receptor? Question 23 options: Binding causes steric hindrance of ACE2 to the receptor binding domain (R

Human Physiology: From Cells to Systems (MindTap Course List)

9th Edition

ISBN:9781285866932

Author:Lauralee Sherwood

Publisher:Lauralee Sherwood

Chapter12: Body Defenses

Section: Chapter Questions

Problem 15RE

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The following reactions are all antigen(Ag)-antibody(Ab) complexes. Match the description with the best reaction. Use each option only once.1. Antibodies react with soluble antigens and when they do, a complex forms that comes out of solution (e.g. is now insoluble).2. Reaction with insoluble antigens (a particle such as a cell with an antigen), rather than a soluble antigen.3. Antibodies coat antigens and enhances phagocytosis4. Antibodies with their antigen involve the complement proteins; can cause the invading organism to lyseAnswer choices to MATCH with the above sentences are:-Agglutination-Precipitin-Complement Fixation-Opsonization
Question 10 of 14 Which of the following are true about MHC class I and MHC class II peptide loading? Select all that apply. MHC class I peptide loading occurs in four steps. Peptide loading of class I molecules generated from intracellular proteins occurs in the endoplasmic reticulum. ⒸMHC class II molecules are loaded before they are part of a vesicle capable of fusing with a phagolysosome. Peptide loading of class II molecules occurs later in the secretory pathway than that of MHC class I molecules.
Neutralizing antibodies are effective at preventing infection or toxicity mediated by pathogens or their toxic products. In fact, nearly all vaccines currently in use function by eliciting neutralizing antibodies. One example is the tetanus vaccine, in which neutralizing antibodies are generated against an inactivated form of the tetanus toxin (the tetanus toxoid). The most important feature of a neutralizing antibody is having high affinity for the antigen. being efficient at activating the complement cascade. having a high degree of multivalency, such as being a pentamer or hexamer of immunoglobulin monomers. being present at a high concentration in the circulation. 0 0 0 0
You can choose one or more than one option Antibodies: IMMUNOLOGY basic have two identical antigen-binding sites. consist of two identical heavy chains and two identical light chains. are secreted by plasma cells are produced by T lymphocytes during adaptive immune response can bind their constant heavy chain region to phagocytes Which of the following proteins are transmembrane proteins? CELL BIOLOGY basic integrin oestrogen receptor phospholipase C adenosine triphosphate (ATP) synthase growth factor receptor What are the correct statements? MOLECULAR BIOLOGY advanced A mutation located within a promoter can change the gene expression. An mRNA can be differentially spliced according to the tissue. RNA transcribed by the RNA polymerase II are translated The end of the transcription process requires a specific DNA sequence A reverse transcriptase can polymerise either a DNA or an RNA strand. Which of the following cells kill other cells by exocytosis of…
Some viruses have mechanisms to down-regulate MHC class I protein expression on the surface of cells in which the virus is replicating. This immune evasion strategy might prevent effector CD8 cytotoxic T cells from recognizing and killing the virus-infected cells. Would this immune evasion strategy also prevent the initial activation of virus-specific CD8 T cells? Yes, because no viral peptide:MHC class I complexes would form to activate CD8 T cells. No, because dendritic cells would take up infected cells and cross-present viral peptides to activate CD8 T cells. No, because some presentation of MHC class I complexes with viral peptides would occur before the virus could down-regulate all the surface MHC class I protein. Yes, because this immune evasion strategy would also function in dendritic cells, even if the virus doesn’t replicate in dendritic cells. No, because the type I interferon response induced by the virus infection will up-regulate MHC class I expression and override the…
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Experiments are performed to analyze protein tyrosine phosphorylation in response to TCR stimulation. For these experiments, T cells are stimulated with anti-CD3 antibody, and then lysates are prepared and run on a protein (SDS-PAGE) gel to separate the proteins by molecular weight. The proteins are transferred from the gel to a membrane for immunoblotting using an antibody that binds to all phosphorylated tyrosine residues in any protein; this antibody is called ‘anti-phospho-tyrosine antibody,’ and is abbreviated as anti-P-Y. The results are shown in the figure below. You confirm that the mutant T cells express normal levels of all the proteins detected in the WT cells, including PLC-g, SLP-76, ITK, ZAP-70, LCK, LAT, and the CD3 and TCRz proteins. Based on these data, which of the following proteins (biotin, hygromycin, and streptavidin) can rule out its presence? Briefly explain your answer. What protein is most likely defective in the mutant cells and why? For the protein you…
alpha:beta TCRs are membrane-bound proteins comprised of two polypeptides linked by a disulfide bond. Both polypeptide components of the alpha:beta TCR are members of the immunoglobulin superfamily, and each of their domains share structural similarity with regions of antibody proteins. However, due to the different functions of TCRs versus antibodies, the overall domain organization of the TCR is not the same as for an antibody. In the figure below, describe three features that are incorrect illustrations of the alpha:beta TCR.
To what cell-surface receptor does the SARS-CoV-2 Spike protein bind? a. What type of genome does SARS-CoV-2 have? Please help explain in less than 5 sentences! Thank you
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	Binding causes steric hindrance of ACE2 to the receptor binding domain (RBD).
	Antibodies interact with antigens using a lock-and-key interaction
	Antibodies against the NTD recruit antibodies against the receptor binding domain (RBD).
	Antibodies against the NTD are not protective.
	Binding causes a conformational change in the RBD domain.