Which of the following enzymes is inhibited as a result of insulin binding to its receptor? glycogen synthase pyruvate kinase acetyl-CoA carboxylase glucose-6-phosphate dehydrogenase glycogen phosphorylase
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- Which of the following enzymes are activated after insulin binds to its receptor? (select all that apply) Protein Phosphatase-1 Glycogen Synthase Lipase Acetyl CoA Carboxylase Glycogen phosphorylase Glycogen phosphorylase kinaseWhich of these enzymes/complexes will insulin activate in the liver? Choose all that apply. Glycogen synthase Glycogen phosphorylase Acetyl-CoA carboxylase Carnitine shuttle PFK-1 FBPase-1Lantus differs from "normal" insulin in that: Select one: Oa. The usual insulin molecule has been combined with zinc isophane Ob. A glycine has been substituted in at A21, and two new arginines have been added as B31 and B32 *. An aspartic acid has been substituted for proline at B28 Od. A "C-peptide" chain has been added Oe The proline at B28 and the lysine at B29 have been reversed
- Insulin stimulated glucose uptake takes place in all of the following except- 1. heart 2. skeletal muscle 3. liver 4. adipose tissueWhich of the following glycolytic enzymes catalyzes the conversion of fructose-1,6-bisphosphate into the two product molecules dihydroxyacetone phosphate, and glyceraldehyde-3-phosphate? phosphoglycerate kinase pyruvate kinase malate dehydrogenase aldolase phosphofructokinaseFor an individual whose liver is regulated by glucagon binding, when energy is needed - what is the major carbon source used to produce acetyl CoA? Fatty acids Glucose Glyoxylate Amino acids
- What is the full regulatory pathway of glycogen synthase and glycogen phosphorylase by insulin and the GPCR pathway?For an individual whose liver is regulated by glucagon binding, when energy is needed - what is the major source of carbon skeletons used to produce TCA cycle intermediates? Amino acids Glucose Fatty acids GlyoxylateWhich of the following conditions is most likely to force a muscle cell to metabolize glucose anaerobically(fermentation) under normal oxygenation ? - Glyceraldehyde-3-phosphate dehydrogenase deficiency - Lactate dehydrogenase deficiency -Pyruvate kinase deficiency -Aldolase deficiency - Cytososic Glycerol-3-phosphate dehydrogenase deficiency
- What type of regulation would be expected when anaerobic metabolism is occurring in the muscle? Select all that apply. O Activation of pyruvate dehydrogenase kinase O Increased levels of calcium to activate pyruvate dehydrogenase phosphatase O Phosphorylation of pyruvate dehydrogenase O Inhibition of pyruvate dehydrogenase complex O Increased levels of NADH to activate citrate synthase O Increased levels of NADH to inhibit alpha-ketogluterate dehydrogenase complex O Increased levels of acetyl CoA to activate pyruvate carboxylase for gluconeogenesisWhich of the following enzymes are activated after epinephrine/ glucagon bind to their receptors? (select all that apply) Glycogen phosphorylase kinase Acetyl CoA Carboxylase Lipase Glycogen phosphorylase Glycogen Synthase Protein Kinase AList reaction or pathways of fatty acid oxidation and biosynthesis affected by insulin and glucagon.