Which has a higher percentage of negative charge at physiological pH (7.4), leucine with pI = 5.98 or asparagine with pI = 5.43?

Q: Calculate the pI value of GE- dipeptide   The pKa values of the terminal amino and carboxyl groups…

A: Calculate the pI value of GE- dipeptide ?

Q: Pentapeptide has a sequence of APEDS Structure of pentapeptide in its proper ionization state at pH…

A: The question is based on the concept of biomolecules. We have to draw pentapeptide and calculate…

Q: lonization State of Histidine Each ionizable group of an amino acid can exist in one of two states,…

A: “Since there are multiple questions and it is not mentioned that which one has to be solved so I am…

Q: Protection factors provide information on the stability of individual amino acids in proteins. Why…

A: Hydrogen/deuterium exchange (HDX) monitored by mass spectrometry (MS) is a promising technique for…

Q: 8) A neutral amino acid with a pKa: of 4.56 and a pKa2 of 8.30 is dissolved in a solution with a pH…

A:

Q: Glutamic acid has three ionizable groups. The pKa of a-COOH is 2.19; a-NH 3+, 9.67; and the R-group,…

A: Given - Pka of α-COOH of glutamic acid = 2.19            PKa of α-NH3+ of glutamic acid = 9.67…

Q: A professor was preparing a manuscript for publication in which she reported that the pI of the…

A: The average of the similarly ionizing groups is the Pl of most of the amino acids that have an…

Q: Consider a peptide: Glu-Glu-His-Trp-Ser-Gly-Leu-Arg-Pro-Gly-His If the pKa values for the…

A: If the pH of the solution is greater or equal to the pKa of side chain then the side chain will be…

Q: Explain the difference in the pKa values of the carboxyl groups of alanine, serine, and cysteine.

A: The compounds in which both amino (NH2) and carboxylic acid (COOH) group are present are known as…

Q: What is the net charge on the tripeptide His-Glu-Lys at pH 7? The table below gives the pKa's of the…

A: Apart from the main -NH2 and -COOH groups, histidine has a side group (imidazole ring) with pKa =…

Q: Estimate the pl values of the following peptides: a. Ser-lle and b. Gly-Tyr-Val.

A: The question is based on the concept of biomolecules . we have to calculate isoelectric point for…

Q: A given glycine solution was titrated against NaOH and pH of the final solution was 4.8. Given that…

A: Given amino acid is glycine.  pKa1 is given as 2.34 and pKa2 is given as 9.60.  Concentration of…

Q: A given glycine solution was titrated against NaOH and pH of the final solution was 4.8. Given that…

A: In the amino acid has the two acidic hydrogens will be present. The first most acidic hydrogen is…

Q: A tripeptide contains lysine (R= -(CH₂)4NH2), phenylalanine (R= -CH₂C6H5) and glycine (R= -H). It…

A:

Q: The pKa of the amino and carboxyl groups on alanine are 9.9 and 2.4, respectively. Under…

A: pKa of amino group=9.9 pKa of carboxyl group=2.4 pH=7.4

Q: QUESTION 1 Use these pKa values to caloulate the charge on the peptide below at pH 6. alpha COOH 2.0…

A: “Since you have asked multiple question, we will solve the first question for you. If youwant any…

Q: Estimate the pI of a dipeptide Cys-Asp assuming that the pKa values for αα-NH3+, αα-COOH, side chain…

A: The question is based on the concept of peptides. we have to identify the isoelectric point of given…

Q: B. Show the structure of the following amino acids where the Zwitterion formed and calculate the pl.…

A:

Q: 3. A homopolymer of histidine (polyhistidine) adopts an alpha helix structure at pH 9 but is…

A: Proteins undergoes denaturation and unfolds due to variation in pH or in higher acidic or basic pH…

Q: Give the numbers of peptide bond present in given structure, structure is given at pH 10.5,  find…

A: The CO- NH bond is called peptide bond. A peptide bond connects two Amino acid units. Amino acid…

Q: The peptide cys-leu-glu-ala-cys-lys is at pH 7 in oxidizing conditions. Part a) Draw the peptide's…

A: The given peptide is cys-leu-glu-ala-cys-lys. Given pH = 7

Q: An amino acid's guadinine side chain has a pKa of 12.5 what is the ratio of uncharged to charged…

A: An amino acid's guanidine side chain has a pKa of 12.5. The ratio of uncharged to charged guanidine…

Q: What is the isoelectric point for the peptide MNPQR at pH 7? Draw the structure, including the…

A: The mentioned peptide is MNPQR.

Q: what is the overall charge on the peptide : Pro- Glu-Tyr-Gln-Arg at pH=11

A: A polypeptide or simply peptide is an entity that contains amino acids bonded to each other by…

Q: If the pl for asparagine is 5.43, draw the structure at a pH of 9.5?

A: The pl for asparagine = 5.43 pH = 9.5

Q: Alanine has pKa values of 2.34 and 9.69. Therefore, alanine exists predominately as a zwitterion in…

A: More the pH value; less the value of pKa, for alanine at pKa, alpha-COOH = 2.34, the deprotonation…

Q: This is a three-part question about a tripeptide. Answer all three sub-questions. The pKR of side…

A:

Q: QUESTION 1 Use these pka values to calculate the charge on the peptide below at pH 6. alpha COOH 2.0…

A: T: Threonine, pKa: 9 S: Serine Y: Tyrosine, pKa: 10 M: Methionine C: Cysteine, pKa: 8 F:…

Q: shows the specificity pockets. The S₁ pocket has a glutamic acid in the bottom, the S₂ pocket is…

A:

Q: what is the overall net charge on the peptide KKSG at pH 7.0?

A:

Q: what is the net charge of the peptide Arg-Ala-Phe-Leu at pH at 8?

A:

Q: b. Draw phi-psi angles about a valine from a short peptide indicating: 1) a phi-angle of+100° and 2)…

A: The phi-angle is referred as the dihedral angle between the groups attached to the nitrogen of the…

Q: Consider the structure of the peptide below. Name it using the three-letter abbreviation.…

A: Amino acids can be defined as the organic compound containing an amino group and carboxylic group.…

Q: Solve this

A: Proteins are formed by condensation reaction of amino acid in which by product such as water is…

Q: Which of the following peptides have a net positive chargeat pH 7? (a) Gly-Ser-Lys, (b) Pro-Leu-Ile,…

A: Among the 20 common amino acids, five have a side chain which can be charged. At pH=7, two are…

Q: The pKa values for Lysine are 1.92/ 9.99/13.8. At what pH will the amino acid not migrate in an…

A: We have given  the pKa values for lysine as follows 1.92, 9.99, and 13.8. and ask to find at what pH…

Q: (a) Redraw the tripeptide in zwitterionic form (b) Explain how ESI-MS can be used to determine…

A: Amino acids are chemical compounds that contain amino and carboxyl functional groups with a side…

Q: Why is the Alanine predominantly zwitterionic at its PI?

A: The PI is referred to the isoelectric point and is a pH of a solution where the molecule is…

Q: If the Dipeptide Experiment was run--without step 1, no acetylation--using the amino acids Valine…

A:

Q: What is the pI for the polypeptide ALRHEN? Use pKa of 8 for the N-terminus and 4 for the C-terminus

A:

Q: The pKa for the side chain amino group in lysine is 10.4. If we were working at physiological pH…

A: At pH below the pKa for the amino acid is  protonated and at  pH above the pKa then it is…

Q: Three peptides were obtained from a trypsin digestion of two different polypeptides. indicate the…

A:

Q: The term used to separate a mixture of enantiomers of amino acids using chiral reagents? A)…

A: When enantiomer of mixture are separated using chiral reagent is called isomeric resolution . In…

Q: Estimate the net charge of the polypeptide chain Ala-Arg-Val-His-Asp-Gln at physiological pH and at…

A: The given polypeptide chain is Ala-Arg-Val-His-Asp-Gln. The structure of the polypeptide…

Q: Are the other polytypes 1H and 3R of PtX2 have been investigated?

A:

Q: What is the net charge of arginine in a solution of pH 1.0?

A:

Q: His-Met-Asp-Tyr-Phe-Ser within this peptide, which amino acid residue is the most hydrophobic and…

A: Hydrophobic amino acids are those with side-chains that do not like to reside in an aqueous…

Q: What is the percentage of the negatively-charged species of the tripeptide Val-Leu-Ser at pH 7.0?

A: At pH = 7, the carboxyl terminal will have a full -1 charge. At pH = 7, we need to use…

Spectroanalytical Methods

Spectroanalytical methods measure the wavelength and intensity of radiations that are either emitted or absorbed by a molecular or atomic species. These methods are useful for evaluating the electronic or atomic arrangement of the molecules of a given analyte.