Which ester, C or D, is more reactive in nucleophilic acyl substitution?Explain your reasoning.

Q: Draw a general Mechanism for Nucleophilic Aromatic Substitution (NAS) reaction

A: Aryl halides are less reactive towards nucleophilic substitution due to resonance effect (+ R) of…

Q: Denote how many nucleophilic centers are present in the following nolecular structure (in case of…

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Q: Draw a general Mechanism for Electrophillic Aromatic Substitution (EAS) reaction

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Q: (a) Draw two different halo ketones that can form A by an intramolecular alkylation reaction. (b)…

A: Given compound,

Q: Where will a nucleophile initially bond to the structure of carvone, provide a reason

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Q: Draw the mechanism that shows how α-D-allopyranose converts to α-D-allofuranose under acidic…

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Q: Devise a synthesis of attached compound from the indicated startingmaterial, organic compounds…

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Q: Draw a complete mechanism for the protection of ethyl acetoacetate using ethylene glycol. explain…

A: We have to predict the mechanism for the protection of the ethyl acetoacetate using ethylene glycol.…

Q: What two molecules were condensed in an aldol reaction to form the compound H. and of H. and H. and…

A: The Aldehydes and ketones are two molecules which are condensed in an aldol condensation reaction to…

Q: Rank the following according to increasing reactivity with 1 as the least reactive, and 4 as the…

A: The reactivity order for nucleophilic acyl substitution is as follows:

Q: From the given structures which is (a) an acid halide? (b) a secondary amide (c) an aldehyde…

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Q: Draw the reactivity series for nucleophilic substitution at the carbonyl carbon. (You may exclude…

A: Reactivity series for nucleophilic substitution at the carbonyl carbon?

Q: Which reacts fastest & slowest with m-chloroperbenzoic acid, why?

A: We know that   The mCPBA is peroxy acid it react with alkene to form epoxide.  the electrophilic…

Q: a. What alkene would give only a ketone with three carbons as a product of oxidative cleavage? b.…

A: b.

Q: Draw the mechanism with curved arrows (Williamson Ether Synthesis). Please provide detailed…

A: Williamson synthesized the ether from alcohol

Q: List A-D in order of increasing ability of a nucleophile to displace a leaving group in a…

A: a) & b)  Aqueous acetone is a protic solvent (the water H-bonds tightly to F-) so iodide will…

Q: Which of the following statement(s) is(are) FALSE? a. Deactivating aryl groups decreases the energy…

A: The question is based on the concept of organic reactions. We have to explain the mechanism of…

Q: Decide which compound in pair is more reactive in electrophilic aromatic substitution reaction…

A: In electrophilic substitution reaction benzene reacts acts as nucleophile . So compound which have…

Q: Why is bond B longer than bond A in the given protonated epoxide?

A: Given a protonated epoxide:

Q: draw the step-wise mechanism (arrow pushing) of the acid catalyzed fischer esterification for the…

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Q: Explain the General Mechanism—Electrophilic Aromatic Substitution ?

A: Electrophilic aromatic substitution reaction involves the replacement of H-atom of benzene ring by…

Q: Explain why compound A does not undergo an E2 elimination with strong base.

A: For the structure to be more stable it has to have the bulky phenyl group in the equtorial position.…

Q: In the mechanism for electrophilic aromatic substitution with a diazonium ion as the electrophile,…

A: We can use the concept of hard and soft acid and base. The terminal nitrogen atom of the diazonium…

Q: Explain why acetanilide is less reactive toward electrophilic substitution than aniline.?

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Q: Rank the species below in order of increasing nucleophilicity in protic solvent.

A: Nucleophile are species which have excess of electron density either have filled orbital or lone…

Q: LDA is the base of choice for carbonyl compound to completely convert into enolate. Why?

A: The full form of LDA is Lithium diisopropylamide. It has isopropyl groups create hindrance and make…

Q: What effect would the nonreversible decomposition of acetoacetic acid have on the equilibrium…

A: Le Chatelier's principle: This principle is used to predict the effect of a change in conditions on…

Q: Draw the mechanism for electrophilic aromatic substitution.

A: Electrophile: from the word electrophile electro means electrons and phile means love. Totally…

Q: Explain the mechanism for nucleophilic acyl substitution ?

A: Nucleophilic substitution is the reaction of an electron pair donor, nucleophile. In nucleophilic…

Q: Explain the major step of a nucleophilic acyl substitution ?

A: The functional groups that undergo nucleophilic acyl substitutions are called carboxylic acid…

Q: Please provide complete explanation. Thank you! Is recrystallization necessary in synthesizing…

A: Interpretation- We have to tell that , Is recrystallization is necessary  in synthesizing…

Q: List TWO nucleophiles that would react with the epoxide belowwith the opposite regioselectivity…

A: Epoxides - Epoxide is an cyclic ether. The 3 membered ring unstable due to ring strain. The C-O…

Q: Propose a mechanism for the α,β-elimination reaction.

A: A mechanism for the α,β-elimination reaction has to be given

Q: Which one  would be most reactive toward electrophilic aromatic substitution?

A: Aromatic electrophilic substitution reaction: Aromatic electrophilic substitution reactions are the…

Q: base ? A B

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Q: Propose a stepwise mechanism for this reaction. The bicarbonate ion will act as a base in the…

A: The given reaction is,

Q: Benzoyl chloride undergoes nucleophilic substitution at a faster rate than methyl propanoate because

A: Nucleophilic attacks on both benzoyl chloride and methyl propanoate are examples of nucleophilic…

Q: Provide an example including a full detailed mechanism of a carbonyl addition in acid. Provide an…

A: Carbonyl compound like aldehyde and ketone undergoes electrophilic and nucleophilic addition…

Q: (a) Draw two different halo ketones that can form A by an intramolecular alkylation reaction. (b)…

A: Given compound,

Q: Explain why aprotic conditions favor a kinetic enolate ?

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Q: Order of reactivity towards nucleophilic substitution reaction of the compounds

A: Order of the reactivity towards nucleophillic substitution reaction of the compound

Q: (a) Why are alkyl halides insoluble in water? (b) Why is Butan-l-ol optically inactive but…

A: Chirality and thereby the optical isomerism in organic compounds is caused by the presence of…

Q: 1. Rank the following according to increasing reactivity (1 - least reactive, 4 - most reactive in a…

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Q: Determine whether attached nucleophilic acyl substitution is likely to occur.

A: Nucleophilic substitution reaction involves the substitution of a leaving group by a nucleophile.…

Q: Please draw the mechanism for the nitration of benzene by using a mixture of nitric and sulfuric…

A: Nitration of benzene is an electrophilic aromatic substitution reaction. HNO3 - Nitric acid H2SO4 -…

Q: Which is a reasonable intermediate in an aldol reaction of propanal?

A: In aldol condensation two carbonyl molecules condensed to form betahydroxyaldehyde or…