Which arrestin is required for activation of phosphorylation of MDM2 during chronic Iso stimulation?use the following Figures 1and 2 respectively to explain please aIP:bIgG ARRB1GSTWB:p53WB:ARRB1GST-ARRB1WB:GSTWB:p53GST-ARRB1GSTNucleusARRB1IsoARRB1IP:MDM2+p53MergedWB:p53WB:MDM2IP:MDM2LysateIsoIP:MDM2LysateIP:MDM2LysatepcDNAArrb1WB:p53Arrb1-Q394LWB:p53WB:p53WB:MDM2WB:ARRB1WTArrb1-1- y-H2AX (arbitrary units)2.52.01.51.00.5.0DNA damageMouse thymusIsoLY294002-NucleusP = 0.015p53 protein levels (arbitrary units)+1.21.0-p53 levels0.8-0.6-0.4-WB:y-H2AXWB:histone0.2-0fWB:p53WB:histoneWB:LDHSalineIsoP = 0.023bIsoLMB1 2 3WTNucleusIsoICINucleusIsoICIWB:p53WB:B-tubulin+++-++H-89+Ns Iso Iso Ns Iso Ns IsoWB:p53WB:FOXO3aWB:p53WB:histoneWB:LDH4 5 6 7Arrb1-- Arrb2-/-WB:p-MDM2(Ser 166)WB:MDM2WB:p-MDM2(Ser 166)WB:MDM2Figure 1 Chronic catecholamine stimulation leads to p53 degradation andaccumulation of DNA damage via ARRB1/AKT-mediated activation ofMDM2. a, Isoproterenol infusion leads to accumulation of DNA damage and

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Description: Which arrestin is required for activation of phosphorylation of MDM2 during chronic Iso stimulation?use the following Figures 1and 2 respectively to explain please aIP:bIgG ARRB1GSTWB:p53WB:ARRB1GST-ARRB1WB:GSTWB:p53GST-ARRB1GSTNucleusARRB1IsoARRB1IP

A family of proteins known as arrestins is crucial for controlling cellular reactions and G…

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Which arrestin is required for activation of phosphorylation of MDM2 during chronic Iso stimulation? use the following Figures 1and 2 respectively to explain please

Biology 2e

2nd Edition

ISBN:9781947172517

Author:Matthew Douglas, Jung Choi, Mary Ann Clark

Publisher:Matthew Douglas, Jung Choi, Mary Ann Clark

Chapter16: Gene Expression

Section: Chapter Questions

Problem 38CTQ: A scientist discovers a virus encoding a Protein X that degrades a subunit of the elF4F complex....

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