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under the same cell culture conditions that lead cultured normal cells to reduce their growth rates, what happens to malignant cells
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- Which is true for cancer cells: 1) Cell death occurs after a determined number of cell divisions 2) Contact with other cells reduces chance of cell division 3) Cell division occurs in the presence of stop signals.The growth fraction of the cancer types A 8, C, and D are 23%, 45%, 56%, and 78%, respectively. Which type of cancer is more suceptible to the chemotherapy?Why are histopathologists interested in the percentage of mitotic cells in a tissue biopsy? 1.High rates of cell division (i.e. a high mitotic index) are characteristic of tumours 2.Low rates of cell division (i.e. a low mitotic index) are indicative of tumours 3.Mature differentiated cells continue to go through the cell cycle 4.They are interested in looking for misshapen cells.
- #1) Hyperplastic growth are not cancerous yet but show a higher than normal proliferation rate. True False #2) When cancer cells have not spread beyond its original site, the term used to describe it is benign growth intraepithelial neoplasia carcinoma stage 3 carcinoma in situ #9) Cancer cells generally have missense mutations in p53 gene, resulting in truncated p53 normally active p53 dominant negative p53 inactive p53 #10) Single or double stranded breaks in DNA activate Chk 1 and 2 kinases, which phosphorylates p53. This results in --- in the level of p53 in the cell. increase decreaseHow are cells in a biopsy specimen from a tumoridentified as malignant?Name the six fundamental properties of malignant tumours. Which of these properties are amenable to study in a cell culture model of cancer and why?
- In order for certain cancers to propagate, they require a growth factor known as Vascular Endothelial Growth Factor (VEGF). What does VEGF signal the cell to do and how does this promote the propagation of cancer cells?Part A and B A. What is the normal function of the Rb protein? A) Rb prevents the cell cycle from proceeding unless the cell is prepared to do so B) Rb causes cells to undergo apoptosis C) Rb promotes Cdk activation D) Each of the other selections is true E) Rb repairs damaged DNA B. How do tumors arise? A) When cell proliferation occurs at a higher rate than cell death B) When someone is infected with a tumor from another person C) When cell death occurs at a very high rate D) When cell proliferation occurs at a very low rateDiscuss the behaviors of cancer cells that maydifferentiate their growth from that of normal cells.
- Exposure to test compounds for several days is commonly used to determine if they cause an inhibition of cell proliferation. What words in this sentence are nominalizations?you have isolated a specific terminally differentiated cell type from a patient for stem cell therapy.why didn't you choose to isolate some adult stem cells and what's the best cellular potency level you will be able to acheive and how?In your own words, explain how cancer cells differ from normal cells in regard to the following: Apoptosis