Three molecules from a combinatorial library are given below: HO. D HO 3 O 10 5 omby Finding a new drug typically requires at least 5000 failed compounds. Assuming that the substituents shown in the structures above can be used at any of the diversity sites, what is the minimum number of ADDITIONAL substituents you would need to use in order to give a good probability of finding a new drug? 7 t ww OH
Three molecules from a combinatorial library are given below: HO. D HO 3 O 10 5 omby Finding a new drug typically requires at least 5000 failed compounds. Assuming that the substituents shown in the structures above can be used at any of the diversity sites, what is the minimum number of ADDITIONAL substituents you would need to use in order to give a good probability of finding a new drug? 7 t ww OH
Chapter22: Carbonyl Alpha-substitution Reactions
Section22.SE: Something Extra
Problem 50AP: One way to determine the number of acidic hydrogens in a molecule is to treat the compound with NaOD...
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