This pedigree traces the inheritance of a trait in humans. Based on this pedigree, is the allele for this disease dominant or recessive? Is it sex-linked? Explain. What genotypes are most probable for the individuals labeled 4, 7, and 10?
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- This pedigree traces the inheritance of a trait in humans.
- Based on this pedigree, is the allele for this disease dominant or recessive? Is it sex-linked? Explain.
- What genotypes are most probable for the individuals labeled 4, 7, and 10?
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- How many affected females and males does this pedigree show? (2) Who is the proband? (3) How many generations are included? (4) What kind of inheritance pattern is the disease-causing allele in this pedigree? Why? (5) Who have the same genotype as the proband? Why?Using the pedigree chart, explain: a) The number of generations seen. b) If all blue-coloured shapes are affected with disease X- how many males are affected? how many females are affected? c) Does this disease have a dominant or recessive inheritance pattern? Justify your answer.Cystic fibrosis (CF) is an autosomal recessive trait. A three-generation pedigree is shown below for a family that carries the mutant allele for cystic fibrosis. Note that carriers are not colored in to allow you to figure out their genotypes. Normal allele = F CF mutant allele = f What is the genotype of individual #13? A) ff B) FF C) Ff D) it is impossible to tell
- This pedigree traces the inheritance of a rare disease in humans. a. Based on this pedigree, is the allele for this disease dominant or recessive? Explain. b. What genotypes are possible for the individuals labeled 1, 2, and 3?Albinism in humans is inherited as a simple recessive trait.Determine the genotypes of the parents and offspring for the following families. When two alternative genotypes are possible,list both.(a) Two parents without albinism have five children, four withoutalbinism and one with albinism.(b) A male without albinism and a female with albinism havesix children, all without albinism.Below is a pedigree of a human genetic disease in which solid color indicates affected individuals. Assume that the disease is caused by a gene that can have the alleles A or a. a) Based on this pedigree, what is the most likely mode of inheritance? b) What is/are the possible genotype/s of person 1? c) What is/are the possible genotype (s) of person 4 ? Explain your answers.
- In a woman who is a carrier of a mutant OTC deficiency allele, her sons who receive the mutant allele will be affected and her daughters will be carriers who may or may not be symptomatic, depending on random X inactivation in the liver. 1) Is this a single gene inheritance or multifactorial disease? 2) Is there a strong genetic or environmental cause to the development of this disease? If both genetic and environmental causes are implicated, you have to indicate each of them separately.The following pedigree shows the pattern of inheritance for an uncommon human disease. Filled symbols indicate individuals with the disease: open symbols indicate normal individuals. Using the symbols A and a, answer the following questions about this pedigree. 1. What are the most probable genotypes of individuals II-9 and II-10 2. If individuals II-1 and II-2 have another child, what is the probability that it will have the disease?The following pedigree represents the inheritance of an autosomal recessive disease in a certain family. 2 5 2 4 5 8 3 4. 6. 1 1- How many males are affected by the disease? 3- How many children did the couple Il-4 and Il-5 have? 4- How many sisters did III-8 have? 5- What is the genotype of III-8? 40
- Take the example of B-thalassemia, an autosomal recessive genetic disease that particularly affects people from around the Mediterranean. This disease is associated with an anomaly of hemoglobin, a protein essential for the transport of oxygen, which is composed of four chains: two alpha (a) and two beta (B). In case of B-thalassemia, the ẞ chains are produced in insufficient or no quantity in an individual homozygous recessive resulting in insufficient production of overall hemoglobin leading to anemia and other physiological challenges. The gene that controls the synthesis of the ẞ chains is located on chromosome 11. Here is part of the coding portion of this gene (which controls a total of 146 amino acids and of which you only see the portion 36 to 41) and one of the targeted mutations: 1. Give the sequence of amino acids from the template and mutated strands. 2. What type of point mutation is it? 3. Using the principles of the theory of evolution, explain briefly and generally why…Using designations "Group A", “Group B," etc., organize the mutant strains into complementation groups. If the result of any cross does not fit your groupings, indicate which cross(es) you have excluded. Consider the consequence if one of the mutations was dominant. You should see that complementation tests could not be used to provide information about dominant mutations. a) If a mutation were dominant, how would the diploid be affected? What effect would this have on the determination of your complementation groups? b) How would you test if any of these trp¯ mutations were dominant?In humans, discoloration of the teeth is controlled by the dentine sialophosphoprotein (DSPP) gene in chromosome 4. The allele for yellow-brown teeth color (D) is completely dominant to the allele for normal teeth (d). This condition has been found to be associated with another genetic condition, Osteogenesis imperfecta, characterized by having brittle bones. One type of this disorder occurs when two copies of the recessive allele (c) for collagen type I (COLIA1) gene are present in an individual's chromosome 17. 2. A man with normal teeth and who exhibits a mild case of Osteogenesis imperfecta (Ol) was born to a father who has discolored teeth and a mother who has normal teeth. Both the man's father and mother do not manifest Oi. What is the genotype of... a.1. the man's father? a.2. the man's mother? a. b. If this man in (a) would marry, what should be the genotype of his wife in order that none of their future children will manifest any of the conditions? Support your answer by…