The transform below undoes a nucleophilic substitution reaction. How would you carry out the reaction in the forward direction using a protic solvent? Undo a nucleophilic substitution. Br
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- A student proposes the following reaction mechanism for the reaction in Model 6. Which step inthis mechanism is least favorable? Explain your reasoning.3. Provide the mechanism for the following reversible nucleophilic addition. Show all curved arrows and intermediates. cat. H+ H₂O HO OH H H 1) protonate to activate 2) nucl adds 3) deprotonate what staysRank the following species in each set from best nucleophile to poorest nucleophile.
- This reaction is an example of conjugate addition of a nucleophile to an a,ẞ-unsaturated carbonyl. H3C LOCH3 H₂O H3C OCH3 OCH3 Draw the two resonance structures of the enolate anion intermediate for this reaction. • Draw an R1 group in place of CoA. The R group tool is located in the charges and lone pairs drop-down menu. • Draw one structure per sketcher. Add additional sketchers using the drop-down menu in the bottom right corner. Separate resonance structures using the symbol from the drop-down menu. • O H CH3 ? [F5) We discussed how oxygen nucleophiles can attack the carbonyl of a ketone or aldehyde, but those are not the only nucleophiles that do so! Consider the reaction below. The product of the reaction is analyzed using IR spectroscopy and there is no carbonyl signal in the IR spectrum. O HCI a) Propose a structure for the product of the reaction in the space above. b) Provide a curved arrow mechanism for the transformation.Use curved arrow formalism to show the mechanism of the reaction shown below.
- Show any reaction that attaches one or two deuterium atom(s) selectively оп carbon.Copy the given reaction and show the mechanism by supplying the appropriate curved arrows. Also, identify the general type of reaction mechanism (polar or non-polar). For polar reaction mechanisms, label the nucleophile and the electrophile. :0: :0 O.. H. HÖ: Hö:Can you continue the synthesis from that final product and turn it into an alkene by doing a different mechanism? Thank you in advance!