The table below gives the plasma drug concentrations (Cp) obtained following an intravenous bolus administration of a 250 mg dose of a drug that exhibited the characteristics of a one-compartment model. Is the decomposition of the drug a first-order or zero-order process? Why? Estimate the half-life of the drug. What is the drug plasma concentration at 75 mins. following the administration?

Introductory Chemistry: An Active Learning Approach
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ISBN:9781305079250
Author:Mark S. Cracolice, Ed Peters
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Chapter3: Measurement And Chemical Calculations
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The table below gives the plasma drug concentrations (Cp) obtained following an intravenous bolus administration of a 250 mg dose of a drug that exhibited the characteristics of a one-compartment model.

  • Is the decomposition of the drug a first-order or zero-order process? Why?
  • Estimate the half-life of the drug.
  • What is the drug plasma concentration at 75 mins. following the administration?
Time (hrs.)
0.5
1.0
2.0
3.0
5.0
7.0
Cp (mcg/L)
68.0
54.0
30.0
18.5
6.0
1.8
Transcribed Image Text:Time (hrs.) 0.5 1.0 2.0 3.0 5.0 7.0 Cp (mcg/L) 68.0 54.0 30.0 18.5 6.0 1.8
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