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- a) The total amount excreted into urine as unchanged drug after an oral tablet (A) of 50 mg was 36.4 mg. After an oral capsule dose (B) of 25 mg the Uo was 20.3 mg. Calculate the relative bioavailability of the tablet A with respect to capsule B. If the absolute bioavailability of the oral capsule is determined to be 0.86 calculate the absolute bioavailability of the tablet dosage form. You are required to list the given data, formula and steps for calculationsThe dose level of Drug XYZ is 60 mg/m2 (Hint: Use the table found in p.19 for the conversion factors)a. What is the dose in body weight (mg/kg) basis in dogs?b. What is the dose in body weight (mg/kg) basis in rats?c. What is the dose in body weight (mg/kg) basis in monkeys?d. What is the dose in body weight (mg/kg) basis in humans? Reference:Guidance for IndustryEstimating the Maximum Safe Starting Dose in Initial Clinical Trials for Therapeutics in Adult Healthy Volunteers the picture attached to my question is page 19 on my pdfCalculate the following dosage: A doctor's prescription for pepcid is 15.5 mg per kg of body weight per dose. For an adult who weighs 135 lbs, calculate the number of grams to be given in a dose.
- A 10-day-old neonate born at 36 weeks gestation and weighing 3265 g is prescribed gentamicin, 4mg/kg in 30 mL/kg of D10W for IV infusion. If an injection contains gentamicin 40 mg/mL, how many milliliters each of gentamicin injection and D10W should be added to an empty IV bag and administered to the patient?The amount of calcium in physiologic fluids can be determined by a complexometric titration with EDTA. In one such analysis, a 0.100-mL sample of blood serum was made basic by adding 2 drops of NaOH and titrated with 0.001 M EDTA, requiring 0.238 mL to reach the end point. Report the concentration of calcium in the sample as miligrams of Ca per 100 mL. (Ca = 40.078 amu).Calculate the oral loading dose (LD) of digoxin for Miss Jones who weighs 60 kg. The desired plasma concentration (Cp) is 1.5 mcg/L, volume of distribution (Vd) is 7.3 L/kg, the salt factor (S) is 1 and bioavailability fraction (F) is 0.7.Give your answer to the nearest whole number of micrograms.The equation below can be used:Loading Dose = Cp desired x VdS x F
- You need to give ranitidine liquid at a dose of 2 mg/kg to a 9-year-old child weighing 23 kg. You have a 150 mg in 10 mL liquid. How much do you need to give for each dose?The order in the MAR is for Atropine 15 mg IV q6h hours PRN. How many mL will you give if the dosage strength is 75mg/7.5mL?A 79 kg man is admitted to hospital following a suspected overdose of drug G. When he is admitted to hospital on the 3rd October at 23:00 his plasma concentration of drug G is 12 mg/mL. Given that the half-life (t½) of drug G is 10.5 hours. What would you expect his plasma concentration of drug G to be at 17:00 on the 5th October? Give the answer in microg/ml. (You may assume that the distribution is complete and the elimination is described by a 1storder process.)