The graph shows the hormone-binding specificity of a hypothetical membrane receptor. The results are for three different hormones, X, Y, and Z. The graph plots the percentage binding capacity of the receptor as a function of hormone concentration for each hormone. Using the graph of percentage binding versus hormone concentration, give the estimated molar (M) concentration for each hormone that yields 50% of maximal binding. [X] = [Y] = [Z] = x10 x10 x10 Binding to receptor as a percentage of the maximum 100 80 60 40 20 | T X 10-8 Hormone concentration (M) 10-6 10-4 N 10-² Based on the concentration that yields 50% maximal binding, which hormone shows the highest binding affinity for the receptor? M M M
The graph shows the hormone-binding specificity of a hypothetical membrane receptor. The results are for three different hormones, X, Y, and Z. The graph plots the percentage binding capacity of the receptor as a function of hormone concentration for each hormone. Using the graph of percentage binding versus hormone concentration, give the estimated molar (M) concentration for each hormone that yields 50% of maximal binding. [X] = [Y] = [Z] = x10 x10 x10 Binding to receptor as a percentage of the maximum 100 80 60 40 20 | T X 10-8 Hormone concentration (M) 10-6 10-4 N 10-² Based on the concentration that yields 50% maximal binding, which hormone shows the highest binding affinity for the receptor? M M M
Chapter21: Medications Used For Musculoskeletal System Disorders
Section: Chapter Questions
Problem 25RQ
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Question
Q9
Transcribed Image Text:Based on the concentration that yields 50% maximal binding, which hormone shows the highest binding affinity for
the receptor?
OX
ΟΥ
ΟΖ
O X, Y, and Z have the same affinity
Measuring adenylate cyclase activity as a function
of hormone concentration reveals whether the
hormone-receptor complex stimulates the
adenylate cyclase cascade. The results of this
experiment are shown in the graph that plots
percentage adenylate cyclase activity against
hormone concentration.
Stimulation of adenylate cyclase
as a percentage of maximum
100
80
60
40
20
X
10-6
Y
10-8
Hormone concentration (M)
10-4
Z
○ Unlike that of X and Y, the hormone-receptor complex for Z does not stimulate adenylate cyclase.
O Only the hormone-receptor complex for X leads to adenylate cyclase stimulation.
O All of the hormone-receptor complexes for X, Y, or Z lead to adenylate cyclase stimulation.
10-²
Considering the relative binding affinities and adenylate cyclase activity as a function of hormone concentration, what can
you conclude about the mechanism of action of the hormone-receptor complexes?
O None of the hormone-receptor complexes for X, Y, or Z lead to adenylate cyclase stimulation.
![The graph shows the hormone-binding specificity
of a hypothetical membrane receptor. The results
are for three different hormones, X, Y, and Z. The
graph plots the percentage binding capacity of the
receptor as a function of hormone concentration
for each hormone.
Using the graph of percentage binding versus
hormone concentration, give the estimated molar
(M) concentration for each hormone that yields
50% of maximal binding.
[X] =
[Y] =
[Z] =
x10
x10
x10
Binding to receptor as a
percentage of the maximum
100
80
60
40
20
X
10-6
Y
10-4
Z
10-8
Hormone concentration (M)
10-²
Based on the concentration that yields 50% maximal binding, which hormone shows the highest binding affinity for
the receptor?
Ox
M
M
M](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2Fa1e502f2-e187-4967-837b-da913ce1db1a%2F84bae7f1-ef53-45fb-b697-f99a0aa7a653%2Fgdlxmzm_processed.png&w=3840&q=75)
Transcribed Image Text:The graph shows the hormone-binding specificity
of a hypothetical membrane receptor. The results
are for three different hormones, X, Y, and Z. The
graph plots the percentage binding capacity of the
receptor as a function of hormone concentration
for each hormone.
Using the graph of percentage binding versus
hormone concentration, give the estimated molar
(M) concentration for each hormone that yields
50% of maximal binding.
[X] =
[Y] =
[Z] =
x10
x10
x10
Binding to receptor as a
percentage of the maximum
100
80
60
40
20
X
10-6
Y
10-4
Z
10-8
Hormone concentration (M)
10-²
Based on the concentration that yields 50% maximal binding, which hormone shows the highest binding affinity for
the receptor?
Ox
M
M
M
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