The amino acid shown below has an ionizable side chain with a pka of 4.When this amino acid is in a more basic solution (i.e., pH 11), it would resemble ionizationstate Cand have a charge of -1HOOHNH₂lonization state ANH3lonization state CHOOHNH3+Ionization state BdybNH₂lonization state D

There are four types of biological macromolecules- proteins, nucleic acids, lipids and…

Answered: The amino acid shown below has an…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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pI is the pH at which an amino acid exists as a zwitterion. A zwitterion has both a plus and minus charge so it is neutral overall. If the pH of a solution of tyrosine is much larger than the pI of tyrosine, which structure below represents the correct protonation state of tyrosine (tyrosine pI is 5.66; the pH of the tyrosine solution is 8.0)? NH NH H,N. HN. HO, OH но но но HO A В D
Lefer to the figure showing the molecular structure of dimethylmercury. H–C-Hg C-H H. Exposure of human skin to a single drop of dimethylmercury can lead to death, as it is highly poisonous and passes easily cell membranes. Based on its structure, why is it able to pass so easily through cell membranes? I-0-I IICIH
Indicate which of the amino acid residues in the following peptide sequence contains a group that has a positive charge for its most likely charge state at pH 10. Asp-Tyr-Lys-GIn-Thr-Ile-Phe-Met-Ser (If none of the amino acids fit the criterion, select "none".) Asp Tyr ооооооооо Lys Gln Thr lle Phe Met Ser none
Polymer beads (resin) made of DEAE (diethylaminoethyl) cellulose are packed in an ion exchange column. The total mass of beads in the column is 8.47 kg. On average, each bead weighs 0.0023 g and has an average of 18.4 * 10° positively charged amine groups that can adsorba negatively charged protein that passes through the column. A solution containing 2.07 mg/L of a protein is maintained at pH 6.3 and is passed through the ion exchange column at 0.215 L/min. The protein has a molecular weight of 154,000. The pk, of the amino groups on DEAE cellulose is 7.1, and the pl of the protein is 5.6. 2. A. How long can the column be operated before reaching 80% capacity (i.e., 80% of the amino groups on DEAE are bound to the protein through an ionic bond)? You may assume that one protein attaches to one + charge on the beads (although it's possible that proteins attach to more than one + charge). B. After reaching 80% capacity, explain what you would do to release the protein attached to the…
Consider the following dipeptides: AC HE TG LR VK How many of the dipeptides in this group that would stick to an anion exchange column at pH-8? Please give me the whole number as the answer, 0, 1, 2 etc Amino Acid pKac pKaN pKaR 9.8 9.9 97 2.4 Glycine Alanine 23 Valios 222
Which of the following is incorrect about the peptide Arg-Asp-Cys-Tyr-Gln-Arg-Glu? O a. Its estimated MW is 770 Da b. None; all the other choices are correct OC. At pH 7, it has a net charge of zero O d. At pH 7, it has six charged groups
You are studying a novel amino acid. It has an alpha-amino and an alpha-carboxylic group, and an ionizable side chain that carries a carboxylic group. A titration curve is shown below. Net charge a CD f 0 1 2 3 4 5 +1 [Select] 0 [Select] 6 7 pH Choose the letter that corresponds to the following charges on this novel acid. +2 [Select] -0.5 [ [Select] -1 [Select] 8 -2 [Select] I 9 10 11 12 13
first amino acid is R second amino acid is L Draw your dipeptide at pH 7.4 What is the Log Kow of the pesticide What is the molar concentration in the octanol phase What is the number for the pesticide How many chiral centers does your assigned pesticide contain?
Place each charge form of alanine under the pH condition where it would be the predominant form. The pK₁ values for the carboxyl group and amino group of alanine are approximately 2.3 and 9.7, respectively. pH 11 H | H₂C-C-COO NH₂ Does not occur in significant amounts at any pH
What average positive charge of an amino acid side chain with pKa 10.9 at a pH value of 11.9? Answer up to two decimals. (Please type answer no write by hend)
Aspartic acid has a side chain bearing a carboxylic acid group; its pK, is ~4. The alpha-carboxylic and alpha-amino groups have pk, values similar to those of alanine, - 2 and ~9, respectively. Determine the net charge on an aspartic acid molecule at the following pH values (match each pH to the best choice). pH = 1 [ Choose ] pH = 2 [ Choose ] pH = 4 [ Choose ] pH = 7 [ Choose ] pH = 9 [ Choose ] pH = 13 [ Choose ] > > >
Shown below is the structure of a polypeptide with the pK, values of its acidic hydrogens. pK = = 10.1 H OH pK, = 9.2 H. pKa = 2.1 H. N-H pK, = 6.0 pKa = 3.9 1. How many peptide bonds are present in one molecule of the polypeptide? [ Select ] II. Over what pH range would this molecule predominantly exist in a state that has a net charge of zero? [ Select ] ZI

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The amino acid shown below has an ionizable side chain with a pka of 4. When this amino acid is in a more basic solution (i.e., pH 11), it would resemble ionization state с and have a charge of -1 dla dy HO NH₂ HO OH NH3+ OH