The aldol reaction is catalyzed by acid as well as by base. Write a detailed mechanism for the acid-catalyzed condensation of acetaldehyde (equation below), and useit to respond.H₂CHacetaldehydeDraw the reactive electrophile.HCIH3COH OHB-hydroxybutanalHCIwarm• You do not have to consider stereochemistry.• You do not have to explicitly draw H atoms.• Do not include lone pairs in your answer. They will not be considered in the grading.• When there is a choice, draw the most stable resonance form.H3C2-butenalH

This reaction is proceed by acid catalysed by acid . In first step enol is formed which further show…

The aldol reaction is catalyzed by acid as well as by base. Write a detailed mechanism for the acid-catalyzed condensation of acetaldehyde (equation below), and use it to respond. H₂C H acetaldehyde Draw the reactive electrophile. HCI H₂C OH O H B-hydroxybutanal HCI warm • You do not have to consider stereochemistry. • You do not have to explicitly draw H atoms. • Do not include lone pairs in your answer. They will not be considered in the grading. • When there is a choice, draw the most stable resonance form. H3C 2-butenal H

The aldol reaction is catalyzed by acid as well as by base. Write a detailed mechanism for the acid-catalyzed condensation of acetaldehyde (equation below), and use it to respond. H₂C H acetaldehyde Draw the reactive electrophile. HCI H₂C OH O H B-hydroxybutanal HCI warm • You do not have to consider stereochemistry. • You do not have to explicitly draw H atoms. • Do not include lone pairs in your answer. They will not be considered in the grading. • When there is a choice, draw the most stable resonance form. H3C 2-butenal H

Organic Chemistry: A Guided Inquiry

2nd Edition

ISBN:9780618974122

Author:Andrei Straumanis

Publisher:Andrei Straumanis

Chapter26: Aldol And Claisen Reactions

Section: Chapter Questions

Problem 5E

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Q3: write the structure and the mechanism of the aldol condensation product of each of the aldehydes. Also one of these aldehydes can undergo aldol addition, but not able condensation. Which one? Why:- a) H₂C CH₂ 3-methylbutanal b) سابع مرکب امرول H₂C 2-methylbutanal
Draw the possible products of this epoxide ring-opening reaction. Use wedge and dash bonds to indicate stereochemistry where appropriate. Ignore any inorganic byproducts. Hll O 1) NaOH / H₂O 2) dilute HCI HIIH Select to Draw
resource from Cengage Learning - Google Chrome ssignment/takeCovalentActivity.do?locator=assignment-take e by the Aldol Condensation (References) OH base + H,0 heat H. H3C H. The aldol reaction is a carbonyl condensation reaction between two carbonyl partners and involves a combination of nucleophilic addition and a-substitution steps. One partner is converted into an enolate ion nucleophile and adds to the electrophilic carbonyl group of the second partner. In the classic aldol reaction, the carbonyl partners are aldehydes or ketones, although aldehydes are more reactive. The product is a B-hydroxy carbonyl compound. In the mixed aldol reaction, the best results are obtained when one of the partners does not have an a-hydrogen. It cannot form an enolate anion and can therefore not undergo self-reaction. The enolizable aldehyde is added slowly to a basic solution of the first aldehyde so that the mixed product is preferentially formed. Under reaction conditions slightly more vigorous…
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Use the reaction given below to answer the following questions. A CH₂OH B H₂O+ C + CH3NH3* D a) What are the approximate pKas of compounds A and B? b) The reaction given above is irreversible. Give a detailed explanation of the reaction and reaction mechanism. Your explanation should indicate your knowledge of the reactivity of carboxylic acid derivatives.
18en the folbwng sequence of reac ond what wo structure of compound AT D (CH,,CULI 2) H,0 HN-CH, H,0 Select one 2.Wnchufthfollewine.comectly represert eet the stepm the rechnsnetamad altalcardensation react
how might you synthesize the following compound using an aldol reaction? draw the structure of the starting aldehyde(s) or ketone(s) you would use Concepts (References) How might you synthesize the following compound using an aldol reaction? Draw the structure of the starting aldehyde(s) or ketone(s) you would use. сно Concepts Reforences How might you synthesize the following compound using an aldol reaction? Draw the structure of the starti CHO • You do not have to consider stereochemistry. • You do not have to explicitly draw H atoms. • Do not include lone pairs in your answer. They will not be considered in the grading. • Draw one structure per sketcher. Add additional sketchers using the drop-down menu in the bottom t Separate multiple reactants using the + sign from the drop-down menu. P. opy sta
1. Provide structures for the products and/or starting materials for the following reactions. Donor Acceptor NaOH CH₂CH₂OH heat loss of H₂O H3C mixed-aldol condensation product NaOH CH₂OH heat *) NOE EtOH #40 2) H₂O* ΕΙΟ CH₂ mixed-Claisen condensation product +HgC. H3C CHS H loss of H₂O mixed-aldol condensation product H3C людете CH3 NaOEt loss of H₂O intramolecular aldol condenstation cyclization product
What is the strongest nucleophile, NH3, CH4, CH3O-, or H2O?
Define Direct Enolate Alkylation ?
2 CH3COOCH,CH3 C2H5O'K*/C2H5OH ---> CH3COCH,COOCH,CH3 [+] Hofmann elimination Clemmensen reduction Claisen condensation O Cannizzaro reaction O Aldol condensation