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If, in addition to the constraints on glucose concentration listed previously, we have in the liver cell ATP concentration == 5 mM and ADP concentration == 5 mM, what is the theoretical concentration of glucose-6-phosphate at equilibrium at pH=7.4 and 37 ∘C? Express your answer to three significant figures and include the appropriate units

If, in addition to the constraints on glucose concentration listed previously, we have in the liver cell ATP concentration == 5 mM and ADP concentration == 5 mM, what is the theoretical concentration of glucose-6-phosphate at equilibrium at pH=7.4 and 37 ∘C? Express your answer to three significant figures and include the appropriate units

Introduction to General, Organic and Biochemistry
Introduction to General, Organic and Biochemistry
11th Edition
ISBN:9781285869759
Author:Frederick A. Bettelheim, William H. Brown, Mary K. Campbell, Shawn O. Farrell, Omar Torres
Publisher:Frederick A. Bettelheim, William H. Brown, Mary K. Campbell, Shawn O. Farrell, Omar Torres
Chapter7: Reaction Rates And Chemical Equilibrium
Section: Chapter Questions
Problem 7.64P: 7-64 As we shall see in Chapter 20, there are two forms of glucose, designated alpha and betawhich...
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If, in addition to the constraints on glucose concentration listed previously, we have in the liver cell ATP concentration == 5 mM and ADP concentration == 5 mM, what is the theoretical concentration of glucose-6-phosphate at equilibrium at pH=7.4 and 37 ∘C?
Express your answer to three significant figures and include the appropriate units.
The first reaction in glycolysis is the phosphorylation of glucose: This is a thermodynamically unfavorable process, with AG" = +13.8 kJ/mol. Part A Submit Previous Answers In a liver cell at 37 °C the concentrations of both phosphate and glucose are normally maintained at about 5 mM each. What would be the equilibrium concentration of glucose-6-phosphate, according to the above data? Express your answer to two significant figures and include the appropriate units. Equilibrium concentration = 1.2x10-7 M Correct glucose + P₁ → G6P + H₂O Keq [G6P] = = = = [G6P] [H₂O] [glucose] [Pi] AG e RT AG 13.8 kJ/mol Note: in the biochemical standard state, the activity of H₂O is assigned a value of 1. [G6P] (1) (0.005) (0.005) Pi + glucose →→→→glucose-6-phosphate + H₂O 13.8 = e 0.008314x310 = -5.36 0.000025 x e 1.2 x 10-7 M Ieview
Transcribed Image Text:The first reaction in glycolysis is the phosphorylation of glucose: This is a thermodynamically unfavorable process, with AG" = +13.8 kJ/mol. Part A Submit Previous Answers In a liver cell at 37 °C the concentrations of both phosphate and glucose are normally maintained at about 5 mM each. What would be the equilibrium concentration of glucose-6-phosphate, according to the above data? Express your answer to two significant figures and include the appropriate units. Equilibrium concentration = 1.2x10-7 M Correct glucose + P₁ → G6P + H₂O Keq [G6P] = = = = [G6P] [H₂O] [glucose] [Pi] AG e RT AG 13.8 kJ/mol Note: in the biochemical standard state, the activity of H₂O is assigned a value of 1. [G6P] (1) (0.005) (0.005) Pi + glucose →→→→glucose-6-phosphate + H₂O 13.8 = e 0.008314x310 = -5.36 0.000025 x e 1.2 x 10-7 M Ieview
This very low concentration of the desired product would be unfavorable for glycolysis. In fact, the reaction is coupled to ATP hydrolysis to give the overall reaction ATP + glucose glucose-6-phosphate + ADP + H+ What is AGO for the coupled reaction? Express your answer to three significant figures and include the appropriate units. AGO!= -18.4 Submit kJ mol Part C Previous Answers Correct ATP + H₂O → ADP +P; +H+ AG = -32.2 kJ/mol Glucose + P₁ → G6P+H₂O AGO! = +13.8 kJ/mol ATP + glucose → ADP +G6P+H+ AG" =−18.4 kJ/mol If, in addition to the constraints on glucose concentration listed previously, we have in the liver cell ATP concentration = 5 mM and ADP concentration = 5 mM, what is the theoretical concentration of glucose-6-phosphate at equilibrium at pH = 7.4 and 37 °C? Express your answer to three significant figures and include the appropriate units. μA Theoretical concentration = Value Units ?
Transcribed Image Text:This very low concentration of the desired product would be unfavorable for glycolysis. In fact, the reaction is coupled to ATP hydrolysis to give the overall reaction ATP + glucose glucose-6-phosphate + ADP + H+ What is AGO for the coupled reaction? Express your answer to three significant figures and include the appropriate units. AGO!= -18.4 Submit kJ mol Part C Previous Answers Correct ATP + H₂O → ADP +P; +H+ AG = -32.2 kJ/mol Glucose + P₁ → G6P+H₂O AGO! = +13.8 kJ/mol ATP + glucose → ADP +G6P+H+ AG" =−18.4 kJ/mol If, in addition to the constraints on glucose concentration listed previously, we have in the liver cell ATP concentration = 5 mM and ADP concentration = 5 mM, what is the theoretical concentration of glucose-6-phosphate at equilibrium at pH = 7.4 and 37 °C? Express your answer to three significant figures and include the appropriate units. μA Theoretical concentration = Value Units ?
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