SN1 SN2 Br YES (example) (ехample) SECONDARY (SUBSTRATE) YES YES TOSYLATE (OTs) GOOD (LEAVING GROUP) (example) (example) (NUCLEOPHILE) (SUBSTRATE) OH (NUCLEOPHILE) :CEN (NUCLEOPHILE) CI (SUBSTRATE) F3C- TRIFLATE (OTf) (LEAVING GROUP) OTs (SUBSTRATE) WATER (H2O) (SOLVENT) DMSO (SOLVENT) :0: H. (SOLVENT)
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- H₂C H H₁C Br NBS CH, CH₂ CC, hv **You may assume that Br-Br is formed by a side reaction that occurs (which we discussed in class). This is useful for one of the steps of the mechanism.Which of the following mechanisms is consistent with the reaction profile shown above? Circle the correct mechanism and justify your choice.In the given synthetic transformation, which basic reaction type best describes the two reactions? (The number in the answer corresponds to the number of reactions) 1. H2SO4, H2O 2. CrO3, py Step 1: choose your answer... Step 2: choose your answer... choose your answer... Substitution Next Proton transfer Addition Elimination Oxidation
- a. Give full curved arrow pushing mec following reaction, and draw a reaction energy diagram. b. On the diagram, indicate the activation energy for the rate determining step, the reaction exothermicity, the positions of the intermediates and the transition states. c. Indicate Lewis and Bronsted acids/bases (LA/LB/BA/BB) for each intermolecular step. energy H₂O H₂SO4 (cat.)/heat LOHWhat is an appropriate multi-step method/mechanism for the transformation shown in the image?? (One of the steps involved here can also be found at the end of Baylis Hillman and Rauhut-currier reactions. The red&green dots show where C from the beginning is now found in the end product.)From the picture and description can you is that a correct mechanism . can you draw the mechanism ? Phosphate Ester (Minor Product): In the mechanism, a nucleophilic attack by the phosphate ion (�2��4−H2PO4−) substitutes the hydroxyl group in the protonated cyclohexanol. This is a minor product due to steric hindrance. The phosphate group is relatively large and bulky, making the substitution reaction less favored. The size of the substituent may lead to a slower reaction rate and decreased likelihood of successful substitution. Ether (Minor Product): In the mechanism, substitution involves another cyclohexanol molecule attacking the hydroxyl group in the protonated cyclohexanol. Steric hindrance and the availability of a more favorable elimination pathway (dehydration) contribute to the ether being a minor product. The proximity of two cyclohexanol molecules for substitution is hindered by steric factors, making elimination more favorable.
- Draw both resonance structures of the most stable carbocation intermediate in the reaction shown. + HCI You do not have to consider stereochemistry. • Do not include anionic counter-ions, e.g., I, in your answer. • • Draw one structure per sketcher. Add additional sketchers using the drop-down menu in the bottom right Separate resonance structures using the symbol from the drop-down menu. ← - CHA ? n ChemDoodleConsider the mechanism of the reaction shown below. Give the structure of the next important organic reaction intermediate along the reaction coordinate. Your answer could be the final product. H. -? HBr Edit Click on the drawing box above to activate the MarvinSketch drawing tool and then draw your answer to this question. If there is no reaction, then check the "no reaction" box below. no reaction3. The following are abbreviated versions of the nucleophilic attack step in each mechanism from the previous page. For each one, add curved arrows and then draw an orbital interaction sketch (including appropriate shading) for the reaction step. Include orbital labels. "A" (add curved arrows) orbital interaction sketch - هم هم (add curved arrows) orbital interaction sketch
- 1.) Draw the least stable resonance form for the intermediate in the following electrophilic substitution reaction. N N Br₂/FeBr3 • You do not have to consider stereochemistry. • Include all valence lone pairs in your answer. • In cases where there is more than one answer, just draw one. [Review topics] 2.) Draw the most stable resonance form for the intermediate in the following electrophilic substitution reaction. [References OH OH Br₂ You do not have to consider stereochemistry. • Include all valence lone pairs in your answer. • In cases where there is more than one answer, just draw one. Br 'BrFor option a), if the methyl group is present, does this mean the reaction has been completed or is not completed, what does this information tell us about the reaction progress? For option b), same question, what information does this range information tell us about the reaction progress?3. Drawing Reaction Mechanism Arrows For the reactions that have TWO starting materials, indicate and label which species is the nucleophile and which is the electrophile. (HINT: Look at the reactants and look at the products to see where bonds form and where bonds break! Using your pK, table and bond polarity predictions will help!) Draw curved arrows to show the movement of electrons for Bond Forming and Bond Breaking in each of the reaction steps Finally, identify and label what type of elementary step is represented for each mechanism -н Name of Elementary Step н-СI: а. Н -H Name of Elementary Step: нс-о-н b. О-н CHз н Н Name of Elementary Step Н-Сі: с O-H CH3 CНз