Sickle Cell Anemia Sickle cell anemia is a group of blood disorders that develop when a person inherits a specific recessive gene mutation. Gene mutations are permanent changes in a genetic sequence. The sickle cell mutation affects the structure of hemoglobin: hemoglobin allows red blood cells to carry oxygen. In order for a person to have sickle cell anemia, they have to inherit two copies of the recessive allele, one from each parent. The diagram shows the genotypes of an unaffected person and a person with sickle cell anemia Explain how inheriting the sickle cell mutation affects the cellular processes of transcription and translation.
Q: reserved to the science resource center when reserving pipette? Aspirator, Graduated Cylinder,…
A: Aspirator should also be reserved to the science resource center when reserving pipette because it…
Q: Suppose we are sure, because of previous studies, that species 1, 2, and 3 are more closely related…
A: See answer in the handwriting
Q: In a blood transfusion, if the donor and recipient blood types are not matched correctly, it may…
A: Introduction: Anyone may experience an ABO incompatibility reaction when you receive the incorrect…
Q: Provide 2 reasons why very young children have high rates of gastrointestinal infections
A: Gastrointestinal infection is an extremely frequent and potentially fatal condition in children. It…
Q: cell anemia is due to a point mutation in the emoglobin polypeptides e cell anemia may result from a…
A:
Q: What is the purpose of pasteurization in performing a simple fermentation process utilizing…
A: Please follow step 2 for detailed explanation.
Q: Explain how cofilin distinguish old filaments from new ones.
A: What is cofilin? By expanding the number of filament endings out of which actin monomers could be…
Q: Sexual Reproduction and Genetic Variation Genetic variation describes the genetic differences in DNA…
A: Crossing over is a key cellular event that occurs during the meiosis I of cell division. During this…
Q: The following drawings form part of a life cycle of a fungus related to a true fungus.
A: there are four phyla for true fungus.they reproduced by formation of spores. fungus does not contain…
Q: Explain how concepts and methods from evolutionary biology can be used to understand human health…
A: One of the branches of biology is known as evolutionary biology. It studies how life first evolved,…
Q: diploid individual is heterozygous for a chromosome rearrangement. The original chromosome and its…
A: Meiosis ensures the production of haploid phase in the life cycle of sexually reproducing organisms…
Q: Can you help me diagram and explain each step involved in the movement of an electron in the…
A: The formation of ATP from ADP and inorganic phosphate (P) in presence of light energy is called…
Q: Are Africanized honey bees a direct or indirect threat?
A: Africanized honey bee causes certain damage because a small degree of disturbance to these hives or…
Q: The FOV on low power of a microscope is measured to be 4.5mm. Using the chart below and the above…
A: *So, our FOV is approximately 4.5mm. *we can perform a simple calculation to determine the…
Q: The specific types of mutations in the gene for the regulatory subunit of cyclic-AMP-dependent…
A: Introduction: Cyclic AMP (CAMP) functions as a second messenger in various cell signalling pathways…
Q: The cells of many eukaryotic organisms have highly specialized systems that specifically repair G-T…
A: Introduction A DNA error known as a DNA mismatch (MM) occurs when two non-complementary bases line…
Q: "If we could turn on telomerase activity in all our cells, we could prevent aging" is true or false.
A: Many potential risks, such as wrinkles, skin folds, a loss of sight, hearing, and sense of smell,…
Q: The recombination frequency of the five loci are as follows. Map the 5 different loci, showing their…
A: Recombination frequency It refers to the frequency of a single crossing of chromosomes between two…
Q: Whether the statement "Cancer therapies directed solely at killing the rapidly dividing cells that…
A: a defect in the regular cell cycle process results in cancer cells, which reproduce abnormally.…
Q: A mother brings in her 8 year old son. She says he complains of a funny color in his urine after he…
A: The color of urine is one of the primary indicator of health and can be used for further diagnostic…
Q: Questions 11-13 are all based on the following information: Human chromosome 4 is about 215 CM long.…
A: The gene that codes for a specific trait, have two alternative forms called alleles. The genotype of…
Q: How does acetylcholine cause a decrease in heart rate?
A: Acetylcholine is a neurotransmitter of autonomic nervous system of human. It releases from…
Q: A. Assumed that the primary contributor to the absorbance of the sample was due to the hemoglobins.…
A: The amount of light beam of particular color absorbed by the substance in the solution can be…
Q: 1. MacConkey agar is selective for what group of bacteria? 2. MacConkey is also a differential…
A: "Media" refers to different types of solid, semi-solid, or liquid formulations that provide similar…
Q: 1. Complete the tables below to compare the following pair of tel Where does digestion begin? What…
A: The following questions related to applied biology, microbiology and organ system. The two subject…
Q: 6.) Which of the following effects the rate oxygen is loaded and unloaded to A. oxygen pressure B.…
A: Oxygen Oxygen is colourless and tasteless gas, that is crucial to living organisms . Oxygen plays an…
Q: The process of meiosis occurs during the cell cycle production and results in …
A: A single cell splits twice during the meiotic process, resulting in four cells with half the…
Q: Even though cancer genomes are overall hypomethylated, explain in detail some genes are…
A: introduction: The study of changes in gene expression and DNA sequencing between cancer cells and…
Q: "Since there are about 1013 cells in an adult human, and about 10¹0 cells die and are replaced each…
A: The process of cell division, which involves duplicating its contents before dividing into two, is…
Q: Which statement does NOT apply to ecological studies? O A unit of time might be the "unit of…
A: Ecological studies are usually done at population level or group level. They help researchers in…
Q: Which of the following is NOT a reason cells regulate gene expression at a level other than the…
A: Introduction : A functional gene product is created through the process of gene expression…
Q: Glucagon and insulinare peptide hormones that are released by the pancreas. The hormones work to…
A: Both insulin and glucagon are peptide hormones. Thus, they possess cell surface receptors. Both…
Q: Compare the genes of an individual’s stem cells with their kidney cells.
A: Introduction Stem Cells have 3 general properties that make them unique among other cell types.1…
Q: Suppose you are working with pea plants like Mendel. You cross two plants, one that is a tall plant…
A: A monohybrid cross is a process of mating between two individuals with dominant genotypes,…
Q: In a population of locusts, the mean wing length is 47 mm, the selection gradient on wing length is…
A: The phenotypic variability in a population is caused by genetic factors, environmental factors, and…
Q: Caffeine is a stimulant found in coffee, tea, soft drinks and other drinks and foods. After…
A: according to the answering guidelines, I'm supposed to answer first three subparts only of the…
Q: 1. The below picture represents diffusion of molecules. Place the following labels in the diagram:…
A: The movement of molecules occurs through active and passive processes in living organisms. Passive…
Q: Explain the Pasteur effect on the aerobic culture of yeast on glucose, where the rate of glucose…
A: Introduction: Yeast uses its nutrition as an energy source when living in anaerobic environments.…
Q: 49. Which of the following hormones plays the major role in expression of the male phenotype? A)…
A: The male phenotype is regulated mainly by three hormones viz. testosterone, dehydrotestosterone and…
Q: 7. Explain why site-directed mutagenesis of aspartate to asparagine in the active site of trypsin…
A: Introduction :- Deoxyribonucleic acids (DNA) in an organism change through the process of…
Q: DNA gyrase decreases the number of positive supercools. What is the result of this process?
A: Thousands of different enzymes catalyze metabolic processes in cells. Enzymes are proteins that…
Q: ou isolate a novel yeast from Antarctica and discover that the yeast has lots of gene for generating…
A: Yeasts are unicellular fungi. They belong to the kingdom of Fungi which also includes molds and…
Q: How to make citric acid (method) Submerge fermentation, surface fermentation etc Why it is…
A: Citric acid is generated in the largest quantities of any organic acid and finds extensive use in…
Q: In which of the following taxa would you find an air capillary? A) Avian reptile B) Non-avian…
A: Taxonomy refers to the the science of naming, and classification of various organisms which…
Q: Researchers have artificially converted a mouse's lissencephalic cerebral cortex to a gyrencephalic…
A: *Transplant spinal tissue into the developing cerebral cortex.
Q: . B. In the rare autoimmune Graves’ disease, antibodies are secreted which over-stimulate thyroid…
A: Grave's disease is an auto-immune disorder and is also known as toxic - diffuse goitre. This disease…
Q: What tool would you use to create a microbe free envi? Please explain
A: Sterilization is the process that destroys or removes all the microbes and their spores from an…
Q: Consider three genes on the same chromosome, Pi-2, Notch, Mu-1. If the recombination frequency…
A: Recombination frequency is described as the percentage of the recombinant phenotype produced in the…
Q: Why do we wash the Ni-NTA beads after applying the clarified lysate so many times? What would happen…
A: HisPur Ni-NTA Magnetic Beads are usually used for small scale affinity purification as well as…
26
Trending now
This is a popular solution!
Step by step
Solved in 2 steps
- Sickle anemia is a favorable mutation. There is only one amino acid different in sickle haemoglobin (S) as compared with normal haemogloblin (A). Persons with sickle cell trait (AS) are able to survive in malarious areas. A couple each having sickle cell trait have five children. What is the probability that they will have a child with sickle disease?Sickle cell anemia is an inheritable red blood cell disorder that results in sickle-shaped red blood cells. The sickle-shaped red blood cells can stick to blood vessel walls and cause a blockage or slow the movement of blood throughout the body. Individuals who are heterozygous produce both normal and sickle-shaped red blood cells which gives them resistance to malaria but they do not develop sickle cell anemia (so heterozygotes are unaffected on the pedigree).Let HbS be the allele for sickle cell anemia and let HbA be the allele for normal red blood cells. Which of the following rows provides the correct genotypes for individuals I-2, I-4, II-1, and III-1? Select one: a. I-2 I-4 II-1 III-1 HbA_ HbAHbS HbAHbS HbA_ b. I-2 I-4 II-1 III-1 HbA_ HbAHbS HbAHbS HbAHbS c. I-2 I-4 II-1 III-1 HbAHbS HbAHbS HbAHbS HbAHbS d. I-2 I-4 II-1 III-1 HbAHbA HbAHbA HbAHbA HbAHbASickle cell anemia is caused by an individual carrying two recessive copies of the hemoglobin gene (hemoglobin gene is labeled Hb, and the recessive version is Hbs). Thus, to have sickle cell anemia, a person must have the genotype HbSHbS. A person that is HbAHbA carries two copies of the normal hemoglobin gene and does not have sickle cell anemia. A person that is heterozygous (HbAHbS) produces enough normal hemoglobin to not have sickle cell anemia but is also resistant to malaria. People that are heterozygous are called “carriers” because they carry the recessive allele but do not express the recessive phenotype. a. A couple are both resistant to malaria but do not have sickle cell anemia. Draw a Punnett square to represent this cross. b. What is the probability that the couple has three children where one child does not have a recessive allele, one child is resistant to malaria and does not have sickle cell anemia, and one child has sickle cell anemia?
- Sickle-cell disease is an autosomal recessive genetic disorder. How many mutated hemoglobin alleles do people with sickle-cell disease have?Another couple is concerned their child will be born with sickle cell anemia. The woman does not have sickle cell anemia. The woman’s mother had sickle cell anemia and her father was a carrier of the sickle cell gene. The man knows that he is not a carrier of the sickle cell gene. What is the probability that the child will be a carrier of sickle cell anemia? please include a punnett squareAnother couple is concerned their child will be born with sickle cell anemia. The woman does not have sickle cell anemia. The woman’s mother had sickle cell anemia and her father was a carrier of the sickle cell gene. The man knows that he is not a carrier of the sickle cell gene. What is the probability that the child will be a carrier of sickle cell anemia?
- Sickle-cell disease (often called sickle-cell anemia) is a disease that is caused by a mutation to the gene that is responsible for producing the protein hemoglobin. Remember that hemoglobin is a protein in the red blood cells which is responsible for carrying oxygen throughout the body. When a person possesses the mutated hemoglobin allele, their red blood cells take on an altered shape and this results in a variety of symptoms ranging from general weakening of the body, damage to the organs and even death. The sickle cell allele is recessive to the healthy allele, thus only individuals that are homozygous for the recessive allele will have sickle-cell disease. Individuals that are homozygous for the healthy allele, along with heterozygous, individuals will be physically healthy. Question: Given that this mutated allele will cause disease and death in individuals, what would you predict to occur to the frequency of this allele in the population? Explain.Sickle Cell Anemia is caused by an abnormal form of haemoglobin, the part of the red blood cell that carries oxygen around the body. The red blood cells become stiff and block blood vessels, causing pain and damage and quickly destroying blood cells, leading to anemia. It is estimated that approximately 1 in 32 000 people in Canada are affected with sickle cell anemia.The disorder occurs when a person inherits two recessive genes for the condition. What are the frequencies of the recessive disease allele and the dominant normal allele in the population's gene pool? Select one: a. Recessive Allele Dominant Allele 0.559% 99.4% b. Recessive Allele Dominant Allele 5.59% 94.4% c. Recessive Allele Dominant Allele 0.313% 99.7% d. Recessive Allele Dominant Allele 0.00313% 99.9%Sickle cell anemia is a disease that is caused by a mutation in the gene that produces hemoglobin. Hemoglobin carries oxygen in red blood cells. The HbA allele produces normal hemoglobin and the HbS allele produces hemoglobin that sticks together and causes red blood cells to sickle. Heterozygous individuals (HbAHbS) produce both normal and "sickle" hemoglobin so the HbA and HbS alleles are codominant. Heterozygotes do not develop sickle cell anemia and are described as having the sickle cell trait. Individuals that are homozygous for the sickle allele (HbSHbS) only produce "sickle" hemoglobin and develop sickle cell disease. A man with the sickle cell trait married a woman with the sickle cell trait. Determine the probability that they will have children with the sickle cell trait or sickle cell disease.Record your answer as a value between 0 and 1 rounded to two decimal places. Answer
- Alpha thalassemia is a hereditary blood condition that results in varying levels of anemia. It is tied to the HB alpha 1 gene and the HB alpha 2 gene on human chromosome 16. The diagram shows the proteins for the hemoglobin genes and the pedigree shows genotypes, designated by the letter X, on the chromosomes for a family affected by the condition. Which represents the predicted level of anemia in a child born to the mother and father in the image with a mutation that results in a genotype of xxxx? Why? A - mild anemia because the loss of 4 genes would equal the loss of the 4 proteins needed for normal alpha hemoglobin B - severe anemia because the loss of 4 genes would equal the loss of the 4 proteins needed for normal alpha hemoglobin C - mild anemia because the addition of 4 genes would produce too many of the proteins needed for normal alpha hemoglobin D - severe anemia because the addition of 4 genes would produce too many of the proteins needed for normal alpha hemoglobinHereditary hemochromatosis is an autosomal recessive genetic disorder that causes the body to absorb too much iron from the diet. This excess iron is stored in the body's tissues and organs, particularly the skin, heart, liver, pancreas, and joints. Because humans cannot increase the excretion of iron, excess iron can overload and eventually damage tissues and organs. Anthony and Melinda met at a support group for individuals who have hereditary hemochromatosis. They were advised by their genetic counselor that it would be risky to have children, since both of them are homozygous for the same recessive allele that causes this condition. Nevertheless, they decided to have a child together. During Melinda’s pregnancy, amniocentesis and genetic testing were performed, and it was confirmed the fetus was homozygous for the hereditary hemochromatosis allele. At birth, the baby appeared completely normal, and as the child continued to grow and mature, the couple were surprised that he seemed…Please help me with the following question: Von Willebrand disease is an inherited bleeding disorder. People with von Willebrand disease take a much longer period for blood to clot/stop than others. von Willebrand disease is either inherited in an autosomal dominant pattern or in an autosomal recessive pattern. Question: what is the genotype of the disorder? what are the phenotypic effects of the disorder? What is happening with the DNA to cause the phenotypic effects?