Retroviruses are used in gene therapy. The goal of gene therapy is to insert in the patient genome a copy of a functional gene that is defective in the patient. Since Retroviruses integrates their genome into the host genome they are ideal gene therapy delivery systems. What would be a potential risk of this type of treatment? The individual treated could be more susceptible to infection by other retroviruses Insertion of the retroviral genome into the host genome can cause dangerous mutations. There are not recognized risks with this gene therapy approach. Genes from the host can be inserted into the retroviruses and laterally moved to other cells.

Retroviruses are used in gene therapy. The goal of gene therapy is to insert in the patient genome a copy of a functional gene that is defective in the patient. Since Retroviruses integrates their genome into the host genome they are ideal gene therapy delivery systems. What would be a potential risk of this type of treatment? The individual treated could be more susceptible to infection by other retroviruses Insertion of the retroviral genome into the host genome can cause dangerous mutations. There are not recognized risks with this gene therapy approach. Genes from the host can be inserted into the retroviruses and laterally moved to other cells.

Biology: The Dynamic Science (MindTap Course List)

4th Edition

ISBN:9781305389892

Author:Peter J. Russell, Paul E. Hertz, Beverly McMillan

Publisher:Peter J. Russell, Paul E. Hertz, Beverly McMillan

Chapter17: Bacterial And Viral Genetics

Section: Chapter Questions

Problem 9TYK

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majority of cancers in human are due to mutations in the p53 gene, however, cancers that are caused by human papillomaviruses doesn't. What is the reason why? please help, i am having a hard time understanding this
Some retroviruses that have a wide host range have been developed for use in treatment of diseases or syndromes. These viruses do not result in a productive infection because they lack critical genes for viral replication, but they do carry DNA sequences that allow them to be packaged into infectious particles. Once in the host cell the viral DNA is released and integrates into the cell's genome. The advantage to this strategy is that the delivery of the DNA is very efficient. What is one possible problem of using a virus that can integrate into the human nuclear genome? Multiple Choice The virus carries genes that will interfere with host cell activities. The viral DNA sequences could still cause a disease. Since the viral DNA sequences no longer contain essential genes for viral replication the host cell may not be able to replicate either. The integration could disrupt an essential gene or genes.
A" is a retrovirus. It can integrate DNA into random sites of human genome. Another virus "B" can integrate DNA at a specific site of human genome. Which one of these viruses would make a better vector for gene therapy? Briefly explain.
Do you see any potential problems with inserting pieces of a retroviral genome into humans? If so, are there ways to combat or prevent these problems? (You may want to look up the definition of a retrovirus.) Explain your answer.
What are the similarities and differences between retroviruses and retrotransposons? It has been hypothesized that retroviruses evolved from retrotransposons. Do you agree with this model? Justify your answer.
Retroviruses can sometimes increase the likelihood of developing cancer. There are two ways that this can happen. Describe these two ways.
Which of the following is a known characteristic that can lead to genetic changes in some viruses? Operons in the viral genome can undergo homologous recombination, leading to genetic rearrangements. Reassortment of segmented genomes can occur if a host cell is co-infected with two different viral strains. RNA polymerases used in replication of the viral genome have proofreading capability. Environmental conditions can trigger the SOS response, which triggers mutations in the viral genome.
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Describe the biosynthesis Filovirus (Marburg virus genome. Discuss the transcription of the virus genome into new virion particles. If you have an RNA virus you cannot just work in a DNA cell as you don’t have the correct enzymes to make more RNA from RNA. include if Filovirus (Marburg virus must package any special enzymes in order to be effective.
15) Why are viruses an ideal candidate for gene delivery in gene therapy? a) What are TWO limitations of viruses as gene delivery vectors in gene therapy?
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		The individual treated could be more susceptible to infection by other retroviruses
		Insertion of the retroviral genome into the host genome can cause dangerous mutations.
		There are not recognized risks with this gene therapy approach.
		Genes from the host can be inserted into the retroviruses and laterally moved to other cells.