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- b) Listed below are several hypothetical nucleophilic substitution reactions. None is synthetically useful because the product indicated is not formed at an appreciable rate. In each case provide an explanation for the failure of the reaction to take place as indicated. OMe HO + OMe + OH HO + CH; OHProvide missing reagents of the following reactions: Please explainFor following substituted benzenes: [1] C6H5Br; [2] C6H5CN; [3] C6H5OCOCH3: Does the substituent activate or deactivate the benzene ring inelectrophilic aromatic substitution?
- Explain the Process of Determining the Mechanism of Nucleophilic Substitution ?what will be the type of interaction of ethane with bromine: a) radicals b) ionic c) nucleophilic d) electrophilic18) The following reaction undergoes three distinct steps: imine formation, electrophilic aromatic substitution, and decarboxylation. Draw each of the intermediates from each of these three steps as well as the final product. BS NH₂ OH heat
- Arrange the given compounds in the increasing order of reaction rate for EAS (Electrophilic Aromatic Substitution) Reaction. H R :ÖH :ö-R :ö:- :N :N-C-RGive a step-by-step mechanism for the following substitution reactions:Rank the following esters from most reactive to least reactive in the first slow step of a nucleophilic acyl substitution reaction (formation of the tetrahedral intermediate): Rank the same esters from most reactive to least reactive in the second slow step of a nucleophilic acyl substitution reaction (collapse of the tetrahedral intermediate).
- Tamoxifen is a drug used to prevent and treat breast cancer. What are all the possible metabolic reactions for this drug? Aromatic hydroxylation Epoxidation ON-dealkylation Benzylic hydroxylation O Epoxidation followed by epoxide hydrolysisPredict the major product of the following reaction and draw it in the space provided. 1) NAOMe Br 2) Meo Ome Br 3) NaOt-Bu 4) HCI, H₂O, heatIdentify all carbonyl compounds that can undergo nucleophilic addition reactions from the following Please explain