NH2 OH OH H2N" 'N' HO ..... O: IZ ZI IZ

Chemistry for Today: General, Organic, and Biochemistry
9th Edition
ISBN:9781305960060
Author:Spencer L. Seager, Michael R. Slabaugh, Maren S. Hansen
Publisher:Spencer L. Seager, Michael R. Slabaugh, Maren S. Hansen
Chapter16: Amines And Amides
Section: Chapter Questions
Problem 16.25E
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What is the amino terminal residue in this peptide?

What is the carboxyl terminal residue in this peptide?

The net charge of this peptide at pH 7.4 would be?

Table 2.1 Typical pk, values of ionizable groups in proteins
Group
Acid
Base
Typical pk
Terminal a-carboxyl group
3.1
Aspartic acid
Glutamic acid
4.1
Histidine
6.0
Terminal a-amino group
-N
H.
8.0
H.
Cysteine
H
8.3
Tyrosine
-4
10.9
Lysine
10.8
Arginine
12.5
"pK, values depend on temperature, ionic strength, and the microenvironment of the ionizable group.
Table 2.1
Biochemistry, Seventh Edition
© 2012 W. H. Freeman and Company
Transcribed Image Text:Table 2.1 Typical pk, values of ionizable groups in proteins Group Acid Base Typical pk Terminal a-carboxyl group 3.1 Aspartic acid Glutamic acid 4.1 Histidine 6.0 Terminal a-amino group -N H. 8.0 H. Cysteine H 8.3 Tyrosine -4 10.9 Lysine 10.8 Arginine 12.5 "pK, values depend on temperature, ionic strength, and the microenvironment of the ionizable group. Table 2.1 Biochemistry, Seventh Edition © 2012 W. H. Freeman and Company
NH2
HO
FOH
H2N
HO.
OH
ZI
IZ
ZI
O:
Transcribed Image Text:NH2 HO FOH H2N HO. OH ZI IZ ZI O:
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