Looking to the future, what changes to the frequency of the sickle-cell allele do you envision as most likely, and why? (In other words, do you envision it becoming more common or less common in human populations?) What factors (technology, climate change, etc) might be driving those changes?
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- The Valyrian elders are doing projections about the future and want to calculate the frequencies of certain genotypes in the next generation. They are only interested in figuring out what proportion of the next generation will bear the signature Valyrian silver hair phenotype. (Assume the allele frequencies remain unchanged from the first part of this question.) A-What will the frequency of the AA genotype be? b-What will the frequency of the Aa genotype be?In the genetics unit you learned that sickle cell anemia is an autosomal recessive condition. In 2016, assume in the City of Markham there are 1000 people out of 300000 people who have sickle cell anemia. Assume global warming continues for the next 50 years and in the year 2066 there are 20000 people out of 500000 in Markham who have sickle cell anemia. a)What are the allele frequencies in 2016? What are the allele frequencies in 2066? Is microevolution evident? b)Due to global warming, assume the numbers of malaria carrying mosquitoes in Markham dramatically increased between 2016 and 2066. What do you believe is the main cause of the microevolution in Markham? (Hint- refer to the 5 factors affecting microevolution and refer back…Nieman-Pick Syndrome involves a defective enzyme, sphyngomylinase. It is usually fatal before the age of 3. The defective allele frequency is 0.01 in Ashkenazi populations. Let’s call the healthy allele A, and the lethal allele a. a) What is the frequency of allele A? Assuming Hardy-Weinberg equilibrium, how many people do you expect to have the three genotypes in a population of 10,000? b) AA:_______ c) Aa:________ d) aa:_________
- Heterozygote advantage is an interesting condition in those individuals who have one of each allele (dominant and recessive) have a higher survival rate than those individuals who are either homozygous dominant or homozygous recessive. Sickle-cell anemia is such a genetic disease associated with the recessive allele. Normal homozygous individuals (SS) have normal blood cells that are easily infected with the malarial parasite. Thus, many of these individuals become very ill from the parasite and many die. Individuals homozygous for the sickle-cell trait (ss) have red blood cells that readily collapse when deoxygenated. Although malaria cannot grow in these red blood cells, individuals often die because of the genetic defect. However, individuals with the heterozygous condition (Ss) have some sickling of red blood cells, but generally not enough to cause mortality. In addition, malaria cannot survive well within these "partially defective" red blood cells. Thus, heterozygotes tend to…Albinism is a rare genetic condition, occurring in only one in every 17,000 to 22,000 individuals in the world (Campbell et al. 2003; Gronskov et al. 2007). What can you conclude about the allelic frequency of an allele globally? Where do you think the a allele would be more commonly found, among the heterozygotes (Aa) or the homozygote recessives (aa)? Why do you say so? What happens to an individual who is albino (aa) or who has very low or lacks melanin pigments in the hair, skin and eyes? Based on your answer in 3, how would you explain the frequency of the a allele?8% of XY individuals are color blind in a population. Assume Hardy-Weinberg conditions. Submit your answer as it is. a) What is the percentage of color-blind XX individuals? b) What is the percentage of XX individuals who are carriers? c) If this population has 1000 individuals with 50% of male and 50% of female, how many carriers are present in this population? Submit your answer as it is. Do not round up.
- A form of learning disabilities and speech impairment results from a recessive mutation in the HERC2 gene. The next 4 questions are about this mutation. In a small Amish village in Ohio, about 5 per 1000 births are affected with this disorder. Assume Hardy Weinberg equilibrium. What is the frequency of the dominant WT HERC2 allele in this small village? A form of learning disabilities and speech impairment results from a recessive mutation in the HERC2 gene. The next 4 questions are about this mutation. Part a: In a small Amish village in Ohio, about 5 per 1000 births are affected with this disorder. Assume Hardy Weinberg equilibrium. What is the frequency of the dominant WT HERC2 allele in this small village? a)0.005 b)0.995 c)0.07 d)0.93 Part b: What is the estimated total number of homozygous dominant individuals in this village of 1000 people? a) 70 b) 930 c) 860 d) 140What do you notice is similar about the distribution of the HERC2 variant for blue eyes and the F374 allele for lighter skin pigmentation? Based on what you know about skin color and human variation, what evolutionary circumstances might have caused this distribution of the blue-eye variant?The eugenic movement was created in the early 20th century by Sir Francis Galton. Its aim was to improve the genetic pool of the human population by selective breeding. One idea was to discourage individuals with Mendelian autosomal recessive diseases to have children. However, the fallacy of this idea is shown by the fact that recessive lethal alleles (that are never found in homozygosity) can persist in populations for hundreds to thousands of generations. Which one of the following statements best explains the persistence of those alleles in populations? There is heterozygote advantage in those populations. Recessive alleles keep being produced by mutation. Recessive alleles cannot be selected against when present in heterozygotes. Genetic drift keeps recessive alleles at a relative high frequency in populations. Consider the action of mutation and of genetic drift in a population. What do you expect genetic variation will be in a…
- 2) The year is 2050. The climate has continued to warm. Areas in northern Canada and Alaska are without snow or ice; the average annual temperature has risen and previously snow-covered areas are now shrub land and some temperate forests. What effect would such a climatic change have on the gene pool of the rabbits? All BUT ONE could apply. A) The allelic frequency has most likely shifted to 85% GG and 15% gg. B) The dominant allele in the gene pool would become G, the previously rare allele. C) The allele for white, g, would be scarce and perhaps nonexistent in the population. D) White rabbits would be at a disadvantage in terms of camouflage and would likely fall prey to predators.Albinism is rare in most human populations, occurring at a frequency of about 1 in 20,000 people. However, the trait occurs at a frequency of 1 in 200 in certain Hopi villages of Black Mesa in Arizona. In light of this example and others that you might be aware of, what can you conclude about particular alleles such as the allele for albinism? Any allele that leads to an abnormal phenotype will be rare in most populations but common in Native American populations. Alleles that produce abnormal phenotypes are never beneficial. An allele that leads to an abnormal phenotype may be beneficial in some environments but harmful in others. An allele that leads to an abnormal phenotype will rise in frequency after many generations. An allele that leads to an abnormal phenotype will soon disappear from a population.A total of 1000 members of a Central American population are typed for the ABO blood group. In the sample, 421 have blood type A, 168 have blood type B, 336 have blood type O, and 75 have blood type AB. Part A Use this information to determine the frequency of ABO blood group alleles in the sample. Recall that when considering genes with three alleles whose frequencies are represented by the variables p, q, and r, the sum of genotype frequencies resulting from trinomial expansion is: (p+q+r)² =p² + 2pq+q2+2pr+r²+2gr = 1