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- Explain the term hematopoietic growth factors (HGFs)?Cancer stem cells (CSCs) are cancer cells (found within tumors or hematological cancers) that possess characteristics associated with normal stem cells, specifically the ability to give rise to all cell types found in a particular cancer sample. There are many biomedical engineering based approaches to detect CSCs. 1) What is the importance and advanatge of detecting CSCs? 2) What kind of systems have been developed to detect CSCs? Describe by giving examples. Please explain in detail with your own words.Quinolones and fluroquinolones affect cell membrane integrity? True or false.
- Detailedly answer the following:Kelly has breast cancer. Her doctors determined her breast cancer wasaggressive, which meant that she needed to undergo chemotherapy. Her doctors recommended a combination of docetaxel (Taxotere®), carboplatin, and trastuzumab (Herceptin®). The following is her blog entry after her second chemo treatment: As far as chemo symptoms go, the biggest has been fatigue. I was just tired, grumpy, and not my usual, peppy self most of the week. Other very minor things—tiny bit of stomach upset at the beginning of the week, but just enough to make me not feel like eating a big steak, not enough to keep me from eating soup or sandwiches. My scalp felt a little irritated—for the girls out there, itwas the feeling of having my hair in a tight ponytail all day and then letting it down, and the follicles just feel prickly—this is normal for several daysbefore the hair falls out. Also, I have a weird dry mouth feeling, so some things taste a little different. But seriously, these are really minor…1) A) List 15 drugs (monoclonal antibodies can be used) used clinically to treat cancer in humans. These targets must be signal transduction pathway components. B) For each drug, list the specific protein targeted. C) For each drug, describe the efficacy of treatment (i.e. what is the success rate in life extension) as well as appropriate cost of treatment whether it be per round or an average annual cost.
- 4.A 65-year old man complains of an increasing resting tremor of hands, stiffness in muscles, a change in his gait. His wife noted anxiety and emotional lability. What diagnosis can be made?a)Concentration of what catecholamine in the neostriatum can lead to such symptoms? Name the desease.b) Write by formulasthe reactions ofsynthesis of this catecholamine and its degradation。 c)What drug therapy is used for treatment of this desease?please help me I can't find answers for these questions: here is the link for the article https://www.pbs.org/wgbh/nova/transcripts/2805cancer.html What type of substances are angiostatin and endostatin and where are they produced? What do they do? A) describe the experiments using cow bones to discover anti-angiogenic substances. Why was this used as a source of these potential proteins? B) describe the “accidental” discovery of a novel antiangiogenic substance because of lab contamination?Outline Knudson’s two-hit hypothesis of retinoblastoma and describe how it helps to explain unilateral and bilateral cases of retinoblastoma.
- A 62-year-old patient is receiving methyltestosterone (Methitest), 200 mg PO daily, for palliation of breast cancer. She asks you why she is taking this particular medication and expresses concern that this medication, like other medications she has taken for treatment of the cancer, will make her feel ill. What should you tell her?What is the advantage of MALDITOF MS?Abnormally high levels of prostate specific antigen (PSA) in a patient's blood is used to screen for prostate cancer. PSA is expressed in nomal, non-cancerous prostate cells. a) Why would elevated levels of PSA be suggestive of prostate cancer given what you know about cancer? Answer in no more than two sentences. b) Are high PSA levels sufficient to confim that a patient has prostate cancer, as opposed to a benign tumor? Why or why not? Explain in one sentence only.