I. Answer the questions given: The Aldol reaction is among the most powerful and versatile methods of carbon- carbon bond formation available to the synthetic chemist. This reaction, and its variants, have made possible the syntheses of many familiar pharmaceuticals. You will design and carry out an aldol condensation reaction between acetone and benzaldehyde to form dibenzalacetone. Answer the following: 1. Write the general reaction for this aldol condensation. 2. Which carbonyl compound is the nucleophile, and which is the electrophile? Draw out the mechanism for this reaction. Why is it called a mixed aldol condensation? 3. You will aim to prepare 2 mmoles of dibenzalacetone. You first must figure out how much of

I. Answer the questions given: The Aldol reaction is among the most powerful and versatile methods of carbon- carbon bond formation available to the synthetic chemist. This reaction, and its variants, have made possible the syntheses of many familiar pharmaceuticals. You will design and carry out an aldol condensation reaction between acetone and benzaldehyde to form dibenzalacetone. Answer the following: 1. Write the general reaction for this aldol condensation. 2. Which carbonyl compound is the nucleophile, and which is the electrophile? Draw out the mechanism for this reaction. Why is it called a mixed aldol condensation? 3. You will aim to prepare 2 mmoles of dibenzalacetone. You first must figure out how much of

Organic Chemistry

8th Edition

ISBN:9781305580350

Author:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote

Publisher:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote

Chapter9: Nucleophilic Substitution And Β-elimination

Section: Chapter Questions

Problem 9.62P

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