How does HbS aggregation occur in sickle-cell anemia? Place the steps in the correct order. Note that deoxyhemoglobin is inthe T state; oxyhemoglobin is in the R state.No aggregationR state Hb shifts to T state Hb.Sickled red blood cellAnswer BankVal interacts with the pocket of a ß chain on another HbS.Additional T state HbS interact with the growing aggregate to form an insoluble fiber.[0₂] decreases due to vigorous exercise or high altitude.

Sickling is seen in sickle cell anaemia where haemoglobin inside the RBC cells sticks together and…

Answered: How does HbS aggregation occur in…

Human Physiology: From Cells to Systems (MindTap Course List)

9th Edition

ISBN:9781285866932

Author:Lauralee Sherwood

Publisher:Lauralee Sherwood

Chapter11: The Blood

Section: Chapter Questions

Problem 3SQE

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Similar questions

Sickle cell anemia is associated with which of the following: Question 27 options: Sticky patches on the hemoglobin surface only present in the T-state Sticky patches on the hemoglobin surface only present in the R-state A mutant form of hemoglobin called Ɣ-hemoglobin Decreased ability to stabilize the T-state with 2,3-bisphosphoglycerate Decreased ability to bind heme because of the Bohr effect
There are almost 500 naturally occurring variants of hemoglobin. Most are the result of a single amino acid substitution in a globin polypeptide chain. Some variants produce clinical illness, though not all variants have deleterious effects. A brief sample follows. HbS (sickle-cell Hb): substitutes a Val for a Glu on the surface Hb Cowtown: eliminates an ion pair involved in T-state stabilization Hb Memphis: substitutes one uncharged polar residue for another of similar size on the surface Hb Bibba: substitutes a Pro for a Leu involved in an _ helix Hb Milwaukee: substitutes a Glu for a Val Hb Providence: substitutes an Asn for a Lys that normally projects into the central cavity of the tetramer Hb Philly: substitutes a Phe for a Tyr, disrupting hydrogen bonding at the alß1 interface Explain your choices for each of the following: (a) The Hb variant least likely to cause pathological symptoms. (b) The variant(s) most likely to show pI values different from that of HbA. (c) The…
A person was found to have very low levels of functional beta globin mRNA and therefore very low levels of the beta globin protein. What problems would this cause for assembling functional haemoglobin molecules?
Relative to the position of hemoglobin A on your gel, where would you expect to find a mutant hemoglobin in which the b-chain glutamic acid residue was replaced by lysine? Sample Wall Number: 1. Normal Hemoglobin- Homoglobin AA 2. Sickle Trait Hemoglobin- Hemoglobin AS 3. Sickle Cell Hemoglobin- Hemoglobin SS 4. The unkniwn hemoglobin sample (showing the mutant sickle cell anemia trait)
Certain antibodies have been shown to bind only to the folded structure oftheir target protein ligand; yet others will bind to both the folded and denatured states of the same protein ligand. Explain this observation.
What causes hemolytic disease of the newborn (erythroblastosis fetalis)? Why does the condition not arise in cases of ABO incompatibility?
Which of the following is FALSE regarding sickle cell anemia? O it is an advantage to be a heterozygote for sickle cell anemia in areas where malaria is prevalent heterozygotes for sickle cell anemia can still have aggregation/polymerization of hemoglobin under conditions of low oxygen O individuals that are sickle cell anemia homozygotes are disadvantaged because they are more susceptible to malaria O the advantage to being a heterozygote for sickle cell anemia disappears when malaria is not an issue
A 6 month old pediatric patient is B-negative. She has received a unit of platelet pheresis that appeared to be bloody. the estimated blood volume in the unit of platelets is estimated to be 5 mLs. Please calculate the dose of RhLg (standard) to be injected to this patient to prevent stimulation of alloanti-D (HINT: It's estimated that 5mL of red blood cells are in the unit of platelets, so think of the 5 mL volume of red blood cells as being "packed cells" rather than whole blood) Need answer ASAP and in short .
2. 3. 4 6. In this image, the bacteria in circles 1 and 4 is demonstrating: presence of catalase • presence of coagulase O absence of catalase O absence of coagulase presence of hydrogen peroxide absence of hydrogen peroxide presence of antibodies absence of antibodies Icst
List 3 differences between sickle cell and b-thalassemia
(e) Two ADP agonists (drugs) were also found to bind to platelets: 2-methylthio-ADP bound with a Kp of 7 µM and 2-(3-aminopropylthio)-ADP bound with a Kp of 200 µM. Can these drugs effectively compete with ADP for binding to platelets? Explain your answer.
The vaccine for Haemophilus influenzae type b is called a conjugate vaccine. It is composed of the tetanus toxoid protein conjugated to the capsular polysaccharide of the H. influenzae type b bacteria. When used to vaccinate infants, the antibody response generated by this vaccine would include 0 0 0 0 antibodies that bind only to the protein-polysaccharide conjugate in the vaccine. antibodies to the tetanus toxoid only. antibodies to the bacterial polysaccharide and the tetanus toxoid. antibodies to the bacterial polysaccharide only.

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