Gout is characterized by elevated uric acid concentrations in blood and urine due to a variety of metabolic abnormalities that lead to the overproduction of purine nucleotides. Allopurinol is used in the treatment of gout because this drug, and its metabolic product, alloxanthine, act as inhibitors of: a) Xanthine Oxidase b) PRPP synthetase c) Adenyl succinate synthase d) Hypoxhantine guanine phosphoribosyl transferase e) Nucleotides

Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
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Gout is characterized by elevated uric acid
concentrations in blood and urine due to a variety of
metabolic abnormalities that lead to the
overproduction of purine nucleotides. Allopurinol is
used in the treatment of gout because this drug, and
its metabolic product, alloxanthine, act as inhibitors
of:
а)
Xanthine Oxidase
PRPP synthetase
c)
Hypoxhantine guanine phosphoribosyl
b)
Adenyl succinate synthase
d)
transferase
e)
Nucleotides
Transcribed Image Text:Gout is characterized by elevated uric acid concentrations in blood and urine due to a variety of metabolic abnormalities that lead to the overproduction of purine nucleotides. Allopurinol is used in the treatment of gout because this drug, and its metabolic product, alloxanthine, act as inhibitors of: а) Xanthine Oxidase PRPP synthetase c) Hypoxhantine guanine phosphoribosyl b) Adenyl succinate synthase d) transferase e) Nucleotides
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