explain to me what Isosteric replacements are when talking about strategies for lead molecule modification?

Principles of Modern Chemistry
8th Edition
ISBN:9781305079113
Author:David W. Oxtoby, H. Pat Gillis, Laurie J. Butler
Publisher:David W. Oxtoby, H. Pat Gillis, Laurie J. Butler
Chapter7: Bonding In Organic Molecules
Section: Chapter Questions
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explain to me what Isosteric replacements are when talking about strategies for lead molecule modification?
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