Q: When the (R,R) isomer of the amine shown is treated with an excess of methyl iodide, then silver…
A: Step 1: When (R, R) isomer of the amine is reacted with an excess of methyl iodide and silver oxide,…
Q: Write a structural formula for the imine formed in each reaction
A: The reaction of ketone with primary amine in the presence of an acid catalyst leads to the formation…
Q: What is the effect of acid on the solubility of amines that are water-insoluble based on aniline and…
A: A question about Solubility, which is to be accomplished.
Q: Draw structures to correspond with the following common and systematic names: (e)…
A: Consider the first first structure (e) The structure of N,N-dimethlyformamide is as follows:
Q: a) Explain why the acetamido group is an ortho, para-directing group. Why should it be less…
A: As there are two questions, we have solved the first question for you, and for the rest to be solved…
Q: Lidocaine synthesis consists of two steps, 2,6-dimethylaniline (1) is treated with chloroacetyl…
A: Electrophilic site: Electron deficient centre IR: It gives information about the functional groups
Q: Give the structures of the two substrates that are required to synthesize the following drug against…
A: The molecular structure of the required drug is provided. It can be synthesized by Knorr pyrrole…
Q: Mechanism of conversion of botanic acid to A) ۱_butanol B) 1_Burumobutan C) 1_Buten
A: We have to convert butanoic acid into 1-butanol 1-bromobutane 1-butene.
Q: Show how you will use Modified Gabriel’s Synthesis and Streckers’s Synthesis to prepare…
A: Modified Gaberial Synthesis : Potasium Phthalimide reaction with chloromalonic ester gives…
Q: Describe the following giving the relevant chemical equation in each case :(i) Carbylamine…
A: Carbylamine is the other name for alkyl isocyanide. When primary amines(aliphatic or…
Q: Why is it that benzenesulfonamides of primary amines are more soluble in aqueous alkali than the…
A:
Q: Explain why a secondary amine forms a nitrosamine rather than a diazonium ion when it reacts with…
A: To understand the reaction consider the reaction of a primary amine with nitrosonium ion. The…
Q: A commonly formed side product during the Hoffman rearrangement is a urea. When butanamide is…
A:
Q: The reaction of an ester with an amine is not as slow as the reaction of an ester with water or an…
A: Since you have posted a multiple question, we will solve first one for you. To get remaining…
Q: Give specific examples for the synthesis of the compounds bearing the following functional groups.…
A: Since you have asked multiple questions, we will solve the first 3 part for you. If you want any…
Q: How to use streckers synthesis to prepare phenylalanine in the laboratory
A:
Q: 2. Draw the scheme of nifedipine synthesis (name all the products).
A: The drug can be defined as a medcation. They are used to treat and cure diseases. One of the…
Q: Sketch the mechanism (electrophilic aromatic substitution and Friedel/Crafts reaction) for the…
A: In presence of acid or H+ ion N-phenyl anthranilic acid get converted into acridone. In first step…
Q: Sketch the mechanism (nucleophilic aromatic substitution) for the conversion of acridone to…
A: Acridone is a tricyclic compound that has ketone and a -NH group in the middle ring. Two benzene…
Q: Show how you will use Strecker's synthesis to prepare phenylalanine in the laboratory
A: Strecker amino acid synthesis- This method is useful for preparation of amino acids. An aldehyde…
Q: Several additional amine syntheses are effectively limited to making primary amines. The reduction…
A: For the conversion of 1-bromo-3-phenylheptane to 3-phenylheptane-1-amine is shown below.
Q: Explain the mechanism for the acid catalyzed hydrolysis of an amide?
A: Amides are the chemical compounds that are obtained by the condensation reactions of carboxylic and…
Q: There are a number of pharmacokinetic strategies available to change the absorption of a lead…
A: Polarity of a molecule can be decreased either by polar groups or introducing non-polar groups
Q: What is/are the major product(s) obtained from the bromination of dimethylaniline? NME2 FeBr3, Br2…
A: N,N-Dimethylamine group is an ortho/para directing group
Q: please answer the question below a)what protucts would be formed if salicin were treated with…
A: Salicin is an aryl beta-D-glucoside that is salicyl alcohol in which the phenolic hydrogen has been…
Q: Prozac may be prepared via a Mannich reaction using which amine? Benzylamine Methylamine Ethylamine…
A: A chemical reaction in which organic compounds take part is called organic reactions. Organic…
Q: Starting with benzene synthesize the amino acid phenylalanine 1. using the strecker approach 2. by…
A:
Q: Sketch a stepwise mechanism for the reaction of secondary amine with an acid chloride to generate an…
A: We have to give a mechanism for the reaction of secondary amine with an acid chloride to give amide.…
Q: drug synthesis from Buchwald-Hartwig Amination reaction
A: Buchwald Hartwig amination reaction is the type of reaction which is used for the synthesis of…
Q: What is the purpose of formylation of the alpha amine in methionine?
A: There are 20 natural occuring amino acids which are the building block of protein synthesis. 3…
Q: what is prefromulation steps of phenylbutazone ?with illustration?
A: The stage of the development during which physiological properties of a drug substance are…
Q: Reduction of aromatic nitro-compounds using Sn and HCl gives :Select one a. aromatic secondary…
A: Given, Reduction of aromatic nitro compounds using Sn and HCl gives = ? Sn/HCl - is a reducing agent…
Q: Match each item to a choice: Choices: alkene Reductive amination Curtius rearrangement Hoffman…
A: Match the following of amine reactions
Q: Give brief information about the synthesis methods of amides. Show the reaction mechanism for…
A: Amides: These are the organic compounds that consist of -CO-NH2 as a functional group. The general…
Q: H S. NH2 H S- H3CO2C H3CO2C Nafcillin IZ
A: There are many mechanisms in organic chemistry such as nucleophilic substitution, nucleophilic…
Q: (enamine form) (imine form) Porphobilinogen Draw curved arrows to illustrate the movement of…
A: Topic-- Arrow pushing mechanism of the given reaction.
Q: (a). Benzphetamine is a habit-forming diet pill sold under the trade name Didrex. It is prescribed…
A: Stereogenic carbon has 4 different atoms or groups attached to it Hoffman elimination gives less…
Q: Write the chemical equations involved in the following reactions:(i) Hoffmann-bromamide degradation…
A: Chemical equations are the representation of chemical reactions. In a chemical equation, both the…
Q: please give full Synthesis reaction of these drugs i) Acetazolamide ii) Frusemide
A: Drug synthesis is the process of obtaining a new compound from a chemical reaction or series of…
Q: a. What is the amine and coupling components of this azodye? H,CO- -N=N-
A: By seeing the structural and substitution pattern in the given azodye molecules we can decide the…
Q: Suggest a test you will use to show that a given food substance contains protein. Show how you will…
A: The Biuret solution is a blue colour reagent which when comes in contact with the proteins, converts…
Q: Which amines cannot be prepared by the Gabriel synthesis? Explain your choices
A: Gabriel synthesis: Gabriel synthesis is a chemical reaction that transforms an alkyl halide into a…
Step by step
Solved in 4 steps with 3 images
- Primary amines can also be prepared by the reaction of an alkyl halide with azide ion, followed by catalytic hydrogenation. What advantage do this method and the Gabriel synthesis have over the synthesis of a primaryamine using an alkyl halide and ammonia?Primary amines can also be prepared by the reaction of an alkyl halide with azide ion, followed by catalytic hydrogenation. What advantage do this method and the Gabriel synthesis have over the synthesis of a primary amine using an alkyl halide and ammonia?Which amines cannot be prepared by the Gabriel synthesis? Explain your choices.
- Aliphatic amines are more basic than ammonia, whereas aromatic amines are less basic than ammonia. Is that true or false?For the identification tests of amines and amides. What would be the positive result of: - Hinsberg - Quinhydrone - Ramini - Alkaline hydrolysis - Acid hydrolysis - Nitrous acid testWhich amines cannot be prepared by a Gabriel synthesis? Explain your choices. NH2 NH2 NH2 а. b. C. d.
- Explain the following giving a reason in each case Why is an alkylamine more basic than ammonia? Why do primary amines have higher boiling points than the tertiary amines?Early organic chemists used the Hofmann elimination reaction as the last step of a process known as a Hofmann degradation—a method used to identify amines. In a Hofmann degradation, an amine is methylated with excess methyl iodide in a basic solution, treated with silver oxide to convert the quaternary ammonium iodide to a quaternary ammonium hydroxide, and then heated to allow it to undergo a Hofmann elimination. Once the alkene product is identified, working backward gives the structure of the amine. Identify the amine in each of the following cases: a. 4-Methyl-2-pentene is obtained from the Hofmann degradation of a primary amine. b. 3-Methyl-1-butene is obtained from the Hofmann degradation of a primary amine. c. 2-Methyl-1-3-butadiene is obtained from two successive Hofmann degradations of a secondary amine.Write the mechanism for the following reactions: 1. the acid-catalyzed hydrolysis of an imine to a carbonyl compound and a primary amine 2. the acid-catalyzed hydrolysis of an enamine to a carbonyl compound and a secondary amine a. How do the two mechanisms differ?
- Explain why a secondary amine forms a nitrosamine rather than a diazonium ion when it reacts with anitrosonium ion.Account for the experimental behavior of each class of amines (primary,secondary and tertiary) based on their relative reactivities with benzenesulfonyl chloride.a. Explain the effect of acid on the solubility of the water-insoluble amines.