Data for finding log P of p-toluoyl penicillinConcentration of solution 1 is 0.001 M. The consequent solutions were prepared by two-fold serial dilution.Solution numberSolution 1Solution 2Solution 3Solution 4Solution 5Solution 6Solution 7Solution 8Solution 9Solution 10Absorbance (342 nm) of octanol solution, initial4 (overloaded)4 (overloaded)3.36 (too high)1.6580.8310.4820.2680.1730.086 (too low)0.042 (too low)Absorbance(342 nm) of octanol solution, aftershaking with water1.6500.8100.4520.2530.154Determination of logP from your data:Plot a calibration graph using initial absorbance data. Use this calibration graph to find concentrations of penicillin in octanol solutions after shakingthem with water. The difference between initial and new penicillin concentrations in octanol solutions will give you amount of penicillin that movedinto the aqueous phase in each case.Finally, calculate the log P for each solution using the following formula:logP = log-C(octanol)C(aqueous)where C(octanol) is concentration of penicillin in octanol after shaking it with water, and C(aqueous) is concentration of penicillin in water.Once you have several values for log P, choose 3-4 closest values and average them to find a final value of log P. Compare it to the one found

The purpose of the experiment is to determine the partition coefficient (log P) of p-toluoyl…

entration of solution 1 is 0.001 M. The consequent solutions were prepared by two-fold serial dilution. ion number ion 1 ion 2 ion 3 ion 4 ion 5 ion 6 ion 7 ion 8 ion 9 ion 10 Absorbance (342 nm) of octanol solution, initial 4 (overloaded) 4 (overloaded) 3.36 (too high) 1.658 0.831 0.482 0.268 0.173 0.086 (too low) 0.042 (too low) Absorbance(342 nm) of octanol solution, after shaking with water 1.650 0.810 0.452 0.253 0.154

entration of solution 1 is 0.001 M. The consequent solutions were prepared by two-fold serial dilution. ion number ion 1 ion 2 ion 3 ion 4 ion 5 ion 6 ion 7 ion 8 ion 9 ion 10 Absorbance (342 nm) of octanol solution, initial 4 (overloaded) 4 (overloaded) 3.36 (too high) 1.658 0.831 0.482 0.268 0.173 0.086 (too low) 0.042 (too low) Absorbance(342 nm) of octanol solution, after shaking with water 1.650 0.810 0.452 0.253 0.154

Macroscale and Microscale Organic Experiments

7th Edition

ISBN:9781305577190

Author:Kenneth L. Williamson, Katherine M. Masters

Publisher:Kenneth L. Williamson, Katherine M. Masters

Chapter7: Extraction

Section: Chapter Questions

Problem 1Q

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Hexanoic acid was added to an immiscible biphasic solvent sysem, water and CCl4 at 20.0OC and the equilibrium concentrations of hexanoic acid were determined to be 3.66 g/L in H2O and 67.0 g/L in CCl4. Caluclate the distrubution coeffiecent (D1) of hexanoic acid in CCl4 with respect to water.
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