Draw the structures of the compounds mentioned in the questions below. Circle the functional group that can be ionized You must show your calculations. Benzoic acid has a pK, of 4.20. If it is present in urine that has a pH of 5.68, what is the ratio of the concentrations of the ionized to un-ionized chemical? Calculate the fraction of the total amount of benzoic acid that is ionized in the urine. Aniline has a pKa of 4.6. If it is present in urine that has a pH of 5.45, what is the percentage of aniline that is ionized in the urine? A chemical is subjected to a partition coefficient measurement using 1-octanol and water. After equilibration and separation of the phases, the following concentrations of the chemical were measured. 1-octanol phase Water phase 0.139 µg/ml Calculate the log Kow for the chemical. 274 µg/ml
Draw the structures of the compounds mentioned in the questions below. Circle the functional group that can be ionized You must show your calculations. Benzoic acid has a pK, of 4.20. If it is present in urine that has a pH of 5.68, what is the ratio of the concentrations of the ionized to un-ionized chemical? Calculate the fraction of the total amount of benzoic acid that is ionized in the urine. Aniline has a pKa of 4.6. If it is present in urine that has a pH of 5.45, what is the percentage of aniline that is ionized in the urine? A chemical is subjected to a partition coefficient measurement using 1-octanol and water. After equilibration and separation of the phases, the following concentrations of the chemical were measured. 1-octanol phase Water phase 0.139 µg/ml Calculate the log Kow for the chemical. 274 µg/ml
Organic Chemistry
8th Edition
ISBN:9781305580350
Author:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote
Publisher:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote
Chapter4: Acids And Bases
Section4.6: Molecular Structure And Acidity
Problem 1Q: Acid-Base Equilibria Many factors contribute to the acidity of organic compounds. Electronegativity,...
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VIEWStep 2: Draw structure of the compounds and write Dissociation reaction.
VIEWStep 3: Determine ratio of concentration of ionized to unionized
VIEWStep 4: Determine the fraction of the total amount of benzoic acid ionized in urine
VIEWStep 5: Draw structure of the compounds and write Dissociation reaction.
VIEWStep 6: Determine fraction of ionized/unionized
VIEWStep 7: Determine Percentage of aniline that is ionized in Urine
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