Describe the mammalian cell cycle briefly. In your work, include a description of how cyclins and cdks work in general. Specifically, what role do checkpoints play in the cycle and what aspects of the cellular environment do they respond to? When activated, the DNA replication (in G2) checkpoint blocks the activation of M-Cdk and thereby prevents entry into mitosis. How is phosphorylation used to regulate this checkpoint?

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
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Describe the mammalian cell cycle briefly. In your work, include a description of how cyclins and cdks work in general. Specifically, what role do checkpoints play in the cycle and what aspects of the cellular environment do they respond to? When activated, the DNA replication (in G2) checkpoint blocks the activation of M-Cdk and thereby prevents entry into mitosis. How is phosphorylation used to regulate this checkpoint?
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