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-CH3 H3C. CH3 Piquindone ) Complete the blank boxes by filling in the missing structures. ii) Write (by the reaction arrows) the missing reagents for Steps 3, 4 and 5. STEP 1 H3C CO2Et NaOEt, ELOH CO>Et room temp STEP 2 1. NABH4 2. base (same transformation can also be achieved with acid) H3C. `OEt steps STEP 3 H3C, reagents??? `CH3 EtO OEt STEP 4 STEP 5 H3C, H3C reagents??? NaOEt, EtOH STEP 6 Br STEP 7 reagents??? Piquindone

-CH3 H3C. CH3 Piquindone ) Complete the blank boxes by filling in the missing structures. ii) Write (by the reaction arrows) the missing reagents for Steps 3, 4 and 5. STEP 1 H3C CO2Et NaOEt, ELOH CO>Et room temp STEP 2 1. NABH4 2. base (same transformation can also be achieved with acid) H3C. `OEt steps STEP 3 H3C, reagents??? `CH3 EtO OEt STEP 4 STEP 5 H3C, H3C reagents??? NaOEt, EtOH STEP 6 Br STEP 7 reagents??? Piquindone

Chemistry
Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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In the image is a synthesis of the dopamine D2 recpetor antagonist, Piquindone.

i) Complete the blank boxes by filling in the missing structures.

ii) Write the missing reagents for steps 3, 4, 5 and 7.

CH3 H3C -CH3 Piquindone ) Complete the blank boxes by filling in the missing structures. ii) Write (by the reaction arrows) the missing reagents for Steps 3, 4 and 5. STEP 1 H3C. CO2Et NaOEt, EtOH .CO2Et room temp STEP 2 1. NABH4 2. base (same transformation can also be achieved with acid) H3C. OEt steps STEP 3 H3C. reagents??? CH3 EtO OEt STEP 4 STEP 5 H H3C. H3C. N. reagents??? NaOEt, EtOH STEP 6 Br STEP 7 reagents??? Piquindone
Transcribed Image Text:CH3 H3C -CH3 Piquindone ) Complete the blank boxes by filling in the missing structures. ii) Write (by the reaction arrows) the missing reagents for Steps 3, 4 and 5. STEP 1 H3C. CO2Et NaOEt, EtOH .CO2Et room temp STEP 2 1. NABH4 2. base (same transformation can also be achieved with acid) H3C. OEt steps STEP 3 H3C. reagents??? CH3 EtO OEt STEP 4 STEP 5 H H3C. H3C. N. reagents??? NaOEt, EtOH STEP 6 Br STEP 7 reagents??? Piquindone
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