(b) The structure of a drug called tirbanibulin which is used to treat a pre-cancerous skin condition called actinic keratosis is shown below. (1) (ii) (iii) (iv) State Lipinski's Rule of Five (ROF) and Veber's addition to the ROF. Briefly state why the ROF is used in medicinal chemistry? Given that the molecular mass of tirbanibulin is 431.536 g.mol-¹ and its log P is 3.2, apply the ROF and Veber's additional rule to this drug and show clearly how you arrived at your answer. Comment on the outcome of your analysis of the structure in part (iii).

(b) The structure of a drug called tirbanibulin which is used to treat a pre-cancerous skin condition called actinic keratosis is shown below. (1) (ii) (iii) (iv) State Lipinski's Rule of Five (ROF) and Veber's addition to the ROF. Briefly state why the ROF is used in medicinal chemistry? Given that the molecular mass of tirbanibulin is 431.536 g.mol-¹ and its log P is 3.2, apply the ROF and Veber's additional rule to this drug and show clearly how you arrived at your answer. Comment on the outcome of your analysis of the structure in part (iii).