ASSAY - 20 tablets weighing 2.58 g were crushed to a powder. A portion of the crushed powder (0.5283 g) was shaken with 50 mL of 0.1 M HCI, the mixture was filtered and made up to 100 mL. 10 ml of this solution was further diluted to 100 mL with 0.1 M HCI. The measured absorbance of the diluted solution at 276 nm was 0.582. Additional information: A196 = 72.3, stated content = 20 mg Calculate:

Chemistry: The Molecular Science
5th Edition
ISBN:9781285199047
Author:John W. Moore, Conrad L. Stanitski
Publisher:John W. Moore, Conrad L. Stanitski
Chapter2: Chemical Compounds
Section: Chapter Questions
Problem 105QRT
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Orciprenaline (C11H17NO3, 211.258 g/mol) is a bronchodilator used in the treatment of asthma. The BP assay for orciprenaline tablets is
described below. Read the following information carefully and answer the questions below. (Record your answers in decimal notation to the
indicated significant figures OR decimal places)
ASSAY - 20 tablets weighing 2.58 g were crushed to a powder. A portion of the crushed powder (0.5283 g) was shaken with 50 mL of 0.1 M HCI, the
mixture was filtered and made up to 100 mL. 10 mL of this solution was further diluted to 100 mL with 0.1 M HCI. The measured absorbance of
the diluted solution at 276 nm was 0.582. Additional information: A19 = 72.3, stated content = 20 mg
Calculate:
a) The concentration of orciprenaline in the diluted solution in mg/L
Answer =
mg/L (2 decimal places)
b) The actual amount of orciprenaline (in mg) in the powder assayed.
Answer =
mg (1 decimal place)
C) The actual amount of orciprenaline (in mg) per tablet.
Answer =
mg (1 decimal place)
d) The percentage of stated content of per tablet.
Answer =
% (1 decimal places)
Transcribed Image Text:Orciprenaline (C11H17NO3, 211.258 g/mol) is a bronchodilator used in the treatment of asthma. The BP assay for orciprenaline tablets is described below. Read the following information carefully and answer the questions below. (Record your answers in decimal notation to the indicated significant figures OR decimal places) ASSAY - 20 tablets weighing 2.58 g were crushed to a powder. A portion of the crushed powder (0.5283 g) was shaken with 50 mL of 0.1 M HCI, the mixture was filtered and made up to 100 mL. 10 mL of this solution was further diluted to 100 mL with 0.1 M HCI. The measured absorbance of the diluted solution at 276 nm was 0.582. Additional information: A19 = 72.3, stated content = 20 mg Calculate: a) The concentration of orciprenaline in the diluted solution in mg/L Answer = mg/L (2 decimal places) b) The actual amount of orciprenaline (in mg) in the powder assayed. Answer = mg (1 decimal place) C) The actual amount of orciprenaline (in mg) per tablet. Answer = mg (1 decimal place) d) The percentage of stated content of per tablet. Answer = % (1 decimal places)
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