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- 1. Explain why it is NOT possible to treat diseases caused by prions with the same drugs that inhibit nucleic acid replication? 2. Explain how the attachment of viruses to bacterial cells is different from the attachment of viruses to animal cells.2. Use the table below to compare Bacteriophages and Animal Viruses. Use the recorded lecture to find the answers. Also include two example bacteriophages and two examples of animal viruses. Bacteriophages Animal Viruses Attachment Entry Synthesis/Attachment Release 3. Imagine that you are a researcher at a pharmaceutical company charged with developing new drugs against human RNA viral pathogens. Describe at least two drugs targets you might pursue and why you feel that the drugs would not harm the patient.3. Imagine that you are a researcher at a pharmaceutical company charged with developing new drugs against human RNA viral pathogens. Describe at least two drugs targets you might pursue and why you feel that the drugs would not harm the patient.
- 1. Throughout history there are many different types of virus that have caused impacts both small and large. Is there a possibility a virus could be considered a "good virus"? Please provide an argument for both yes and no with the use of a proper example.1. Viruses can be grown in vivo (using live animals such as mice and embryonated eggs) and in vitro (using cell cultures). Explain how these methods (live mice and cell cultures) are used to culture viruses.1. Your doctor tells your friend that he has a viral infection in his throat. The pain is intolerable and he has an upcoming exam to study for. He is mad at his doctor for not prescribing him an antibiotic. How would you explain to him the rationale behind his doctor’s decision? Explain that a virus can’t be treated with an antibiotic and why
- viruses:1. Why must primary cell cultures be restarted every so often when preparing primary cell cultures to observe morphological changes caused by cells infected by a virus? Why are tumor cells preferred? 2. Why are non-enveloped viruses generally more resistant to disinfectants than are enveloped viruses? 3. A public health physician isolated large number of phages from rivers used as a source of drinking water in western Africa. They physician is very concerned that humans might become ill from drinking this water, although she knows that the phages specifically attack bacteria. Why is she concerned?6. Retroviruses have an RNA genome instead of a DNA genome, and the RNA must be copied into the host's DNA. How does this process differ from other reactions in biochemistry? What additional steps must happen for the virus to infect a cell?1. What is fundamentally different about the way viruses reproduce compared to other cellular forms of life? Be specific. 2. Use the table below to compare Bacteriophages and Animal Viruses. Use the recorded lecture to find the answers. Also include two example bacteriophages and two examples of animal viruses. Bacteriophages Animal Viruses Attachment Entry Synthesis/Attachment Release 3. Imagine that you are a researcher at a pharmaceutical company charged with developing new drugs against human RNA viral pathogens. Describe at least two drugs targets you might| pursue and why you feel that the drugs would not harm the patient.
- 2. Luc Montagnier worldly renowned virologist, who first isolated HIV and Noble prize winner, wrote about Covid-19 as man-made virus. He and his team conclude that this virus in different than regular coronavirus, because HIV and Malaria are added to his genome and this cannot happen naturally. Is this one of many conspiracy theories or the truth?1. Pandoravirus salinus is virus that infects amoeba, is very large (1µm) and has a genome composed of double-stranded DNA that is 2.47 Mbp in size (247,000,000 bp). P. salinus has genes not typically associated with viruses, such as genes required for the synthesis of amino acids. In what ways might this force virologists to re-examine the definition of virus?1. Predict the replication step (after it has entered the host cell) for the newly discovered Opiovirus. It has a dsDNA genome. • Draw out your prediction. Include any proteins/enzymes the virus will need to use, bring, or express to carry out the replication. Indicate where it is likely for replication to occur in the host cell.
