A nonapeptide was treated with dithiothreitol to reduce any disulfide bridges, then partially hydrolyzed, giving rise to the following fragments. What was the sequence of the original polypeptide? Phe-Gln-Asn Pro-Arg-Gly-NH2 Cys-Tyr-Phe Asn-Cys-Pro-Arg Tyr-Phe-Gln-Asn

Essentials of Pharmacology for Health Professions
7th Edition
ISBN:9781305441620
Author:WOODROW
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Chapter5: Abbreviations And Systems Of Measurement
Section: Chapter Questions
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A nonapeptide was treated with dithiothreitol to reduce any disulfide bridges, then partially
hydrolyzed, giving rise to the following fragments. What was the sequence of the original
polypeptide?
Phe-Gln-Asn
Pro-Arg-Gly-NH2
Cys-Tyr-Phe
Asn-Cys-Pro-Arg
Tyr-Phe-Gln-Asn
O Cys-Tyr-Phe-GIn-Asn-Cys-Pro-Arg-Gly-NH2
O H2N-Gly-Arg-Pro-Cys-Asn-Gln-Phe-Tyr-Cys
O Gly-Arg-Pro-Cys-Tyr-Phe-Gln-Asn-Cys-NH2
Cys-Pro-Arg-Gly-NH2-Cys-Tyr-Phe-Gln-Asn
O None of these are correct.
Transcribed Image Text:A nonapeptide was treated with dithiothreitol to reduce any disulfide bridges, then partially hydrolyzed, giving rise to the following fragments. What was the sequence of the original polypeptide? Phe-Gln-Asn Pro-Arg-Gly-NH2 Cys-Tyr-Phe Asn-Cys-Pro-Arg Tyr-Phe-Gln-Asn O Cys-Tyr-Phe-GIn-Asn-Cys-Pro-Arg-Gly-NH2 O H2N-Gly-Arg-Pro-Cys-Asn-Gln-Phe-Tyr-Cys O Gly-Arg-Pro-Cys-Tyr-Phe-Gln-Asn-Cys-NH2 Cys-Pro-Arg-Gly-NH2-Cys-Tyr-Phe-Gln-Asn O None of these are correct.
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