A 26-year-old woman complains of the acute onset of anuria, purpura, and mental confusion. Her peripheral blood film displays marked thrombocytopenia and abundant schistocytes. Laboratory studies reveal elevations of bilirubin, creatinine, and lactose dehydrogenase. A skin biopsy shows numerous intravascular thrombi within the dermal microvasculature. What is the most likely diagnosis? Mary-Hegglin anomaly Bernard-Soulier syndrome Immune thrombocytopenic purpura Glanzmann thrombasthenia Thrombotic thrombocytopenic purpura.

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A 26-year-old woman complains of the acute onset of anuria, purpura, and mental confusion. Her peripheral blood film displays marked thrombocytopenia and abundant schistocytes. Laboratory studies reveal elevations of bilirubin, creatinine, and lactose dehydrogenase. A skin biopsy shows numerous intravascular thrombi within the dermal microvasculature. What is the most likely diagnosis?

  • Mary-Hegglin anomaly
  • Bernard-Soulier syndrome
  • Immune thrombocytopenic purpura
  • Glanzmann thrombasthenia
  • Thrombotic thrombocytopenic purpura.
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