20. A pharmacist adds 10 mL of a 20% (w/v) solution of a drug to 500 mL of D5W for parenteral infusion. What is the percent- age strength of the drug in the infusion solution? (a) 2% v/v (b) 2% w/v (c) 1.96% w/v (d) 0.39% w/v 20. (d) 0.39% w/v
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- 18. Esmolol 1.2 g in 500 mL D5W has been ordered at a rate of 100 mcg/kg/min for a client weighting 103.2 kg. Determine the following: a) dosage in mcg/min: b) rate in mL/hr c) Is the dosage administered to the client safe?1. 2. 3. 4. A physician wants to administer an anesthetic agent at a rate of 5 mg/h by IV infusion. The elimination rate constant is 0.2 h¹ and volume of distribution is 20 L. a. How long will it take to reach a drug concentration of 1 µg/ml? b. How long will it take to reach steady state? c. What loading dose should be recommended if the doctor wants the drug concentration to reach 1.25 µg/ml immediately? What is the concentration of a drug 3 hours after administration of a loading dose of 10 mg and the simultaneous infusion of 2 mg/h? The drug has a half-life of 3 h and a volume of distribution of 10 L? A patient was infused for 12 h with a drug (k= 0.4 h¹; Vd= 15L) at a rate of 5 mg/h. What are the concentrations of the drug at 1, 2, 8, 10, 14, and 16 hours since the start of the infusion? Given the following drug concentrations determine k, V₁, CL and half-life for a drug infused at a rate of 200 mg/h for 8 hours. Time(hr) 1 2 4 8 9 10 14 Drug Concentration(mg/L) 27.50 40 48 50…The peak plasma concentration achieved after the first IV dose of drug X is 25 mg/L. The drug’s half-life is 3.5 hours, and it is administered every 12 hours. What will be the peak plasma concentration at steady state?
- When 100 mg of a drug is administered as an IV bolus dose, the plasma concentrations (ug/mL) observed over time (hr) can be described by the following equation: C = 3.6e-0.105t C= 3-6e AUC 36 6 -0.105t 5. Calculate AUC(0-0) 0-105 = 34.28 6. What is the volume of distribution? Dose 100 VD= Co 3-6 7. Calculate the clearance of this drug. CI = KXVD CI = 0•105 x 27-8 %3D %3D Cl=2.9 8. What IV dose would be required to produce an initial plasma concentration of 10 ug/mL?A child weighing 22 lbs, has an infection and the doctor orders erythromycin drops 2.0 mLp.o. q6h. The bottle states that the usual dosage is 20.0-40.0 mg/kg/day, and there are35.0 mg per 1.5 mL. Find the min and max dosage per day in mL. Is the order within therecommended dosage?The biexponential equation for a two compartment model drug is C1,t = 50.0e-1.64t + 20.0e-0.147t. The drug is administered as a rapid IV bolus at t = 0. After 2.00 hours how many mg/l will the drug concentration in the central compartment be.
- A 100 ml vial of alteplase, a thrombolytic drug, contains 100 mg of drug equivalent to 58,000,000 international units to be administered via intravenous infusion. Determine the units administered to a patient who weighs 172 lb at a dose of 0.9 mg/kg and the volume of injection to use. 43,100,200 units: 78.60 mL 50,810,000 units: 75.50 mL O45,500,700 units: 73.80 mL 40,808,800 units: 70.40 mLThe initial plasma concentration of a drug given iv at 8:00am is 210 mg/ml. If the half life of the drug is 6 hours, what will the plasma concentration be at 7:00pm that same day?An IV infusion is to contain 40 mEq of potassium ion and 10 mEq of sodium ion in 500 mL of D5W.Using a 20% w/v potassium chloride injection (MW 74.5, valence of 1) and 0.45% sodium chlorideinjection (MW 58.5, valence of 1), how many milliliters of each should be added to the 500mL bag ofD5W to supply the required ions?
- 6, If Mr. Strong is admitted to the hospital and administered Buprenex, how much will you draw up in the syringe for a 0.6-mg dose? How many milliliters (mL) will be needed per day if the dosage range is 0.3 to 0.6 mg every 6 hours? (Buprenex 0.3 mg/mL.) Please show your calculations. nhohia Use the Internet toAfter oral administration of single 100 mg capsule of an antihypertensive drug to a normal volunteer, the total calculated AUC was 20 mg.hr/L. After intravenous bolus administration of 20 mg, the AUC was 10 mg.hr/L. Calculate the absolute bioavailability of the drug from the tablet applied orally. (10. SLAYT) A) 60% B) 20% C) 40% D) 50% E) 75% What sould be the minimum solubility of an active substance (its molecular weight:500) in the dissolution media to be chosen in order to ensure the sink condition in the paddle method by using a 1 liter volume of beaker of a tablet (its dose strength is 100 mg and tablet weight is 200 mg? (4. SLAYT) 1 mg/ml 200 mg/ml 20 mg/ml 5 mg/ ml 10 mg/ ml