17. As shown below, the amino acid histidine can exist in 4 different protonation states depending on the pH of its environment. a) Which numbered state will histidine exist as at pH 1? pH 11? Neutral pH? b) Which numbered state of histidine could be called a "zwitterion"? =NⓇ HN. 1 OH pka = 3 HN- H 2 pka = 6 HN H³NⓇ 3 pka = 10 HN- H₂N

Chemistry & Chemical Reactivity
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Author:John C. Kotz, Paul M. Treichel, John Townsend, David Treichel
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Chapter24: Biochemistry
Section24.1: Proteins
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17. As shown below, the amino acid histidine can exist in 4 different protonation states
depending on the pH of its environment.
a) Which numbered state will histidine exist as at pH 1? pH 11? Neutral pH?
b) Which numbered state of histidine could be called a "zwitterion"?
HN
H H3N
1
OH
pka = 3
HN.
2
pka = 6
HN-
H3N
3
pka = 10
HN-
H₂N
Transcribed Image Text:17. As shown below, the amino acid histidine can exist in 4 different protonation states depending on the pH of its environment. a) Which numbered state will histidine exist as at pH 1? pH 11? Neutral pH? b) Which numbered state of histidine could be called a "zwitterion"? HN H H3N 1 OH pka = 3 HN. 2 pka = 6 HN- H3N 3 pka = 10 HN- H₂N
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