1.(a) ( ) Trace the course of [1,6-(C-14)-2,5-(C-13)]glucose that is first processed through glycolysis and proceeds into the TCA cycle. For the glycolysis part, use the diagram below to decide where glucose atoms end up in pyruvate. You need to illustrate only the structures of D-glucose, labeling the atoms, and of pyruvate, labeling the origin of the atoms in glucose and the distribution of the carbon isotopes in py- ruvate. After one round of the TCA cycle where will the labeled carbons be found? HO HO (b) (* CH₂OH Glucose HO + 2 NAD+ O + 2 NADH + 2 Pi 2 F0 + 2 ATP OH + 2 ADP 3 + 2 H₂O Pyruvate The formation of oxaloacetate in the TCA cycle is unfavorable with a AG'° = +29.7 kJ/mol. Write the reactions using structural formulas for the formation of oxaloacetate and for the subsequent reaction in the TCA cycle. What particular part of the subsequent reaction makes it very favorable and ensures that oxaloacetate is continually removed to make the next TCA intermediate?
1.(a) ( ) Trace the course of [1,6-(C-14)-2,5-(C-13)]glucose that is first processed through glycolysis and proceeds into the TCA cycle. For the glycolysis part, use the diagram below to decide where glucose atoms end up in pyruvate. You need to illustrate only the structures of D-glucose, labeling the atoms, and of pyruvate, labeling the origin of the atoms in glucose and the distribution of the carbon isotopes in py- ruvate. After one round of the TCA cycle where will the labeled carbons be found? HO HO (b) (* CH₂OH Glucose HO + 2 NAD+ O + 2 NADH + 2 Pi 2 F0 + 2 ATP OH + 2 ADP 3 + 2 H₂O Pyruvate The formation of oxaloacetate in the TCA cycle is unfavorable with a AG'° = +29.7 kJ/mol. Write the reactions using structural formulas for the formation of oxaloacetate and for the subsequent reaction in the TCA cycle. What particular part of the subsequent reaction makes it very favorable and ensures that oxaloacetate is continually removed to make the next TCA intermediate?
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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![1.(a) (
) Trace the course of [1,6-(C-14)-2,5-(C-13)]glucose that is first processed through glycolysis
and proceeds into the TCA cycle. For the glycolysis part, use the diagram below to decide where glucose
atoms end up in pyruvate. You need to illustrate only the structures of D-glucose, labeling the atoms, and
of pyruvate, labeling the origin of the atoms in glucose and the distribution of the carbon isotopes in py-
ruvate. After one round of the TCA cycle where will the labeled carbons be found?
HO
HO
(b) (*
CH₂OH
Glucose
HO
+ 2 NAD+
O + 2 NADH
+ 2 Pi
2
F0
+ 2 ATP
OH + 2 ADP
3 + 2 H₂O
Pyruvate
The formation of oxaloacetate in the TCA cycle is unfavorable with a AG'° = +29.7
kJ/mol. Write the reactions using structural formulas for the formation of oxaloacetate and for the
subsequent reaction in the TCA cycle. What particular part of the subsequent reaction makes it very
favorable and ensures that oxaloacetate is continually removed to make the next TCA intermediate?](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2F7e3218aa-1b65-42a2-9071-7edb43c3a555%2Fa6ac2469-0f91-42d2-96f5-4a8f2340ee4a%2F32c3qnh_processed.png&w=3840&q=75)
Transcribed Image Text:1.(a) (
) Trace the course of [1,6-(C-14)-2,5-(C-13)]glucose that is first processed through glycolysis
and proceeds into the TCA cycle. For the glycolysis part, use the diagram below to decide where glucose
atoms end up in pyruvate. You need to illustrate only the structures of D-glucose, labeling the atoms, and
of pyruvate, labeling the origin of the atoms in glucose and the distribution of the carbon isotopes in py-
ruvate. After one round of the TCA cycle where will the labeled carbons be found?
HO
HO
(b) (*
CH₂OH
Glucose
HO
+ 2 NAD+
O + 2 NADH
+ 2 Pi
2
F0
+ 2 ATP
OH + 2 ADP
3 + 2 H₂O
Pyruvate
The formation of oxaloacetate in the TCA cycle is unfavorable with a AG'° = +29.7
kJ/mol. Write the reactions using structural formulas for the formation of oxaloacetate and for the
subsequent reaction in the TCA cycle. What particular part of the subsequent reaction makes it very
favorable and ensures that oxaloacetate is continually removed to make the next TCA intermediate?
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