1. Cetrizine is a nonsedating antihistamine. The first step in a synthesis of cetirizineinvolves the following Grignard reaction. Give the major product and propose a reasonablemechanism for the following reaction:HCI1)2) HCI, H₂OMgBrdiethyl ether

Carbonyl compounds on treatment with Grignard reagent followed by hydrolysis form alcohols.

Answered: 1. Cetrizine is a nonsedating…

Organic Chemistry

8th Edition

ISBN:9781305580350

Author:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote

Publisher:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote

Chapter18: Functional Derivatives Of Carboxylic Acids

Section: Chapter Questions

Problem 18.42P

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1. Cetrizine is a nonsedating antihistamine. The first step in a synthesis of cetirizine involves the following Grignard reaction. Give the major product and propose a reasonable mechanism for the following reaction: H CI 1) 2) HCI, H₂O MgBr , diethyl ether