1. A drug was administered by rapid IV injection into a 70-kg adult male. Blood samples were withdrawn over a 7-hour period and assayed for intact drug. The results are tabulated below. Using the method of residuals, calculate the values for intercepts A and B and slopes a, ß, k, k12, and k21. Download (.pdf)|Print Time (hours) 0.00 0.25 0.50 0.75 1.00 1.50 2.00 C(μg/mL) 70.0 53.8 43.3 35.0 29.1 21.2 17.0 Time (hours) 2.5 3.0 4.0 5.0 6.0 7.0 C(μg/mL) 14.3 12.6 10.5 9.0 8.0 7.0

1. A drug was administered by rapid IV injection into a 70-kg adult male. Blood samples were withdrawn over a 7-hour period and assayed for intact drug. The results are tabulated below. Using the method of residuals, calculate the values for intercepts A and B and slopes a, ß, k, k12, and k21. Download (.pdf)|Print Time (hours) 0.00 0.25 0.50 0.75 1.00 1.50 2.00 C(μg/mL) 70.0 53.8 43.3 35.0 29.1 21.2 17.0 Time (hours) 2.5 3.0 4.0 5.0 6.0 7.0 C(μg/mL) 14.3 12.6 10.5 9.0 8.0 7.0