17. Why is chronic inflammation a risk factor for cancers? Indicate as many answers as apply.O Mutagenic substances are produced during inflammation.Oncogenic cytokines are produced?Angiogenesis and migration are promoted.Activation of the immune system results in increased visibility of cancer cells.Apoptosis is increased. 3. A novel chemical entity reveals high Pearson correlation coefficients with vincristine and colchicine in the National Cancer Institute's COMPARE analysis for in vitroantitumour profiles. What is its likely mechanism of action?It binds tubulinIt alkylates DNAOIt inhibits angiogenesisOIt inhibits DNA base excision repairO It inhibits dihydrofolate reductase

In chronic inflammation, the process of inflammation begins even if no injury does not end. An…

Answered: . Why is chronic inflammation a risk…

Human Biology (MindTap Course List)

11th Edition

ISBN:9781305112100

Author:Cecie Starr, Beverly McMillan

Publisher:Cecie Starr, Beverly McMillan

Chapter22: Genes And Disease: Cancer

Section: Chapter Questions

Problem 2CT: A textbook on cancer contains the following statement: Fundamentally, cancer is a failure of the...

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1. Describe & explain the pathophysiology of cancer based on the diagram. Reference: https://www.onlinebiologynotes.com/cancer-etiology-pathophysiology-types-diagnosis-and- treatment/ Acquired (environmental) DNA damaging agents: • chemical • radiation viruses Activation of growth- promoting oncogenes NORMAL CELL DNA Damage Failure of DNA repair Mutations in the genome of somatic cells Alteration of genes that regulate apoptosis Malignant neoplasm / Successful DNA repair CANCER Inherited mutations: • Genes affecting DNA repair • Genes affecting cell growth Expression of altered gene products and loss of regulatory gene products Inactivation of cancer suppresor genes Clonal expansion Additional mutations (progression) T Heterogeneity
-Describe the seven hallmarks of cancer i) List the seven hallmarks ii) Connect each hallmark to the type of change -Explain importance of p53 i) Know the function of p53 ii) Explain how loss of p53 can result in several hallmarks of cancer
1. A brief intrwhich introduces ALP as a diagnostic tool in cancer and create a Graphical Abstract to summarise the role of ALP in cancer?
1. Brief introduction which introduces ALP as a diagnostic tool in cancer and create Graphical Abstract to summarise the role of ALP in cancer?
Tissues and differentiation a)Explain what is meant by termination and differentiation ).b) Explain the difference between an oncogenic and a tumour suppressor gene and describe how they are involved in the onset of cancer
Explain what is fundamental aberrations in all cancer cells ?
I understand how nuclear factor-kB (NFKB) works in the inflammatory response but what is the mechanism by which it causes cancer?
. Describe the general relationship that may exist between mutations and cancer
1. True or Flase: Cells must only divide when they receive a signal to divide. 2. BRCA1 is a gene that codes for a tumor suppressor protein. If a person inherits a mutation in BRCA1, it greatly increases his or her risk of developing breast cancer. Are the cancer-causing mutations in the BRCA1 gene more likely to: a) increase expression of the gene b)decrease expression of the gene c)not affect the expression of the gene
1.create a Graphical Abstract to summarise the role of ALP in cancer?With image
What is inflammation? Describe the main characteristics of inflammation. What characterizes chronic inflammatory disorders? What is the role of NFkB in inflammation and cancer? What are the mechanisms and strategies to inhibit excessive and chronic inflammation? answer should be one page long
12.What is field of cancerization? Explain part A and B of this figure. How does it explain field of cancerization?| (A) mutation mutation mutation mutation morphologically normal morphologically abnormal, hyperplastic, dysplastic, or neoplastic (D) tumor 1 tumor 2 (8) 7,8,9 10 wild-type p53 only G-T45. wt p53 NORMAL PATCH FIELD CARCINOMA 17p 3p, 9p, 8p, 189 11g Figure 11.14 The Biology of Cancer (0 Garland Sdener 2014)

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