. Label each factor involved in the reaction of a carbonyl compound as "1" (preferred or "2" (if all else fails). Also, state when site 1 would predominate and/or when site 2 would be the major consideration. a. || H2C-C-A Nu/B Nhen would you consider using site 2 to predict the major product?
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- Propose an efficient synthesis for the following transformation. Use the reagents/conditions below and enter your answer as a string of letters with no spaces or punctuation. но A. H3O* B. conc. H2SO4 C. NaOEt D. t-BUOK Е. HBr F. HBr, ROOR G. TSCI, pyridine H. BH3-THF then H202, NaOH I. Hg(OAc)2, H2O, then NaBH4 J. Br2, UV light K. OsO4, NMO L. MCPBAPlease pronde ne approprate reagents or product. 1.Os0y,TBHP, H20/THF -> 2. TSOH, acetone, PhH,neat 3. AICI3, CH3COCI, CH2C12 2) 1. B200B2,NBS, CC14> 2. Mg, THF;then Pa°Ln, PhBr 3. HNO3 , HzSo4 4. 2n, HCI me Br Me0 (3 meo MeN HN Meo me Br2. Propose a reasonable mechanism for the following reactions. Label each reagent's role in the reaction. Assume aqueous work up to obtain neutral products. b. Ar- HO OH Ar ZnCl₂ Ar Hint: ZnCl₂ is a Lewis Acid.
- Q6 Complete the retrosynthetic analysis. Supply all reagents and precursors, for both parts: A and B. Fewest possible reaction paths should be choiun. Part A V Part B MiSelect the reagent(s) necessary for the given step of these synthesis pathways: Reagents available a. CH3 CH2 COCi f. PB33 b. C6 H5 COCI g. Mg, ether c. AlCl3 h. H2SO4, conc d. NaBH4, ethanol i. SOCI2 e. Н,SO4, dil j. C6H5 CN Scheme 1: он Br CH3 CHa CH3 MgBr CH3 C-H CH,CH3 но CH2CH3 Step 2 : Previous Next Step 7:2: Indicate the product molecules formed in the following multistep reaction sequence. Draw the product after each reaction. Do not draw any mechanisms or reaction intermediates. 1. pyridinium dichromate in dichloromethane 2. ethylmagnesium bromide (excess). then acid quench он 3. tosyl chloride & triethyl amine 4. phenol that was pretreated with sodium hydroxide
- 6. Propose a route to Compound 2 from only bromobenzene and methyl formate as carbon sources, plus any inorganic reagents. Br H OMe Compound 2Select the reagents for the following transformation. Please enter your answer as a string of capital letters with no space in between, for example: ACA A. H/Pt B. I) NANH, 2) H;0 C. IBUOK D. xs HBr E. BryH20 F. NaOEt G. BryCCI, H. EtBr I. HBr J.OYDMS K. KMnO, NAOH cold L. Na/NH M. HBr, ROOR N. 1) RCO,H, 2) H,0" O. 1) BH,. THF 2) H,O,. NaOH P. 1) Hg(OAc),, H,0 2) NaBH, Q Brg, hv R. 1) O, 2) H,O S. HLindlar's cat. T. H,O" U. HgSO,, H,SO,, H20 V. 1) R,BH 2) H,O, N2OH W. 1) xs NANH, 2) H,0 X. xs Bry/CCI Y. HCECN.3. Which of the sequences of reagents given below works best to convert 3-hexene to 3-hexyne? A. 1. HCI 2. NaNH2 B. 1. BH3 THF 2. HO-, H2O2 3. NaNH2 C. 1. NaNH2 2. HI 3. H3O+ D. 1. Br2, CCl4 2. KOH, 200°C E. 1. Cl2, CH2Cl2 2. NaCN (excess)
- 15) Propose a synthetic route to convert 3-methyl-1-butanol into 3-methyl-2-butanol. OH OH A) 1. NaOH; 2. H3O+ B) 1. H₂SO4, heat; 2. NaBH4; 3. H3O+ C) 1. H2SO4, heat; 2. Hg(OAc)2, H2O; 3. NaBH4 D) 1. Hg(OAc)2, H2O; 2. H2SO4, heat; 3. NaBH4 E) 1. NaOMe; 2. BH3-THF; 3. H2O2, NaOH Answer: CHelp me pleaseA) Suggest two possible syntheses for the following target molecule (TM), starting with any aldehyde (start each synthesis with a different aldehyde). It may help to first consider a retrosynthesis of the TM. он CH3. CH-C-CH2CH2CH2CH3 CH3 Hint! Possible aldehyde starting materials: тв для Ph TM