The Effects Of Statins And Its Effect On The Liver Disease And Stroke ( Doc1 )

High cholesterol level is a condition in which the concentration of high density lipids (HDL) specifically cholesterol, has significantly increased in the blood. The build up of these lipids in arteries reduce the supply of blood and hence, oxygen to the heart. Consequently, high cholesterol can lead to stroke or heart attack. Apo – Atorvastatin (Atorvastatin Calcium Tablets) is a medication that helps lower the concentration of cholesterol and other HDL in the blood (Apo-Atorvastatin, 2011) and is manufactured by Apotex Inc.

A systematic search was conducted using PubMed and Google Scholar. The search was conducted using MeSH terms “statin therapy” AND “myopathy” AND “vitamin d” as well as the keyword “prophylaxis”. Limits included English only, humans only, years 2004 to present. UptoDate was searched for key words “statin-induced myopathy”, while Clinical Pharmacology was used for background information. Inclusion and Exclusion criteria were based on best available trials. While the best studies are randomized controlled trials,

Coronary artery disease remains number one killer of the western civilization despite 40 years of aggressive drug and surgical interventions (Esselstyn). Usually, pharmaceutical drugs, such as statin, are given to try to slow the progression, but may provide uncomfortable side effects. In fact, the majority of patients discontinue statins within 1 year of treatment initiation (Maningat). Furthermore, surgery is performed to circumvent clogged arteries and literally bypass the symptoms. In the last year, 500,000 coronary bypass procedures were performed (Swaminathan et al). However, these surgeries can have significant risks, including the potential to cause further heart damage, stroke, and brain dysfunction. Thus, it is evident that these way of treatments may not be enough on its own, and that getting to the

A higher level of fats in the body puts the patient at higher risk for Cardiovascular diseases(CAD). The patient's' family has a history of CAD. Her mom and one of her sister have CAD (Lewis et al., 2014, pp. 733-734). The patient states that she has been taking her meds for cholesterol atorvastatin regularly. Her lipase level was 8272 on 11/11/16 and 2829 on 11/12/16 U/L 1069 on 11/13/16 (Ref range 73-393 U/L). Her HDL cholesterol level was 21 ( ref range>49 mg/dl), LDL Cholesterol level 148 ( ref range: <130 mg/dL). Patient statin drug was on hold because it is contradicted on the patient with an elevated level of ALT 80, 61(Ref range 0-50 U/L) and AST 61 on 11/12/16 and 64 on 11/13/16 (ref range 0-45 U/L). The uncontrolled level of could be the cause of concern for stroke or acute myocardial

They are many treatments for treating high cholesterol. Many people, making changes to their lifestyle doing activities such as eating better, losing weight, and exercising will be enough to lower cholesterol meanwhile others may benefit from medicines. They’re not much side effects from medications used to treat high cholesterol. Statins are the number one drug used to treat high cholesterol. Statins can lower the risk of heart attack or stroke. Other medications can improve cholesterol levels, but they have not been proven to lower the risk of a heart attack or a stroke. Statin side effects can be uncomfortable, making it seem like the risks outweigh the benefits of these powerful cholesterol-lowering medications. (Mayo Clinic Staff) Side effects of statin is muscle pain and damage, liver damage, digestive problems, rash or flushing, increased blood sugar or type 2 diabetes, and neurological side effects.

He has never been on any statin therapy. His most recent lipids were done in January showing total cholesterol 213, triglycerides 172, HDL 61, LDL is 118.

MR. David likewise takes atorvastatin (Lipitor); 10 mg every day, for hypercholesterolemia (hoisted LDL cholesterol, low HDL cholesterol, and raised triglycerides). He has endured this medicine and holds fast to the day by day plan. Amid the previous 6 months, he has likewise taken chromium picolinate,

Strokes are the fifth leading cause of deaths in America. They are also one of the leading causes of disabilities in adults. There are many factors, such as atrial fibrillation and lifestyle factors, which could lead to a potential stroke. There is the atrial fibrillation (shortened to “AFib”) and stroke connection. AFib is the constant and irregular beating of the two atria valves of the heart. The irregular heartbeats can cause blood to form clots in the heart and travel towards the brain. There are other types of risk factors that can lead to strokes, which are medical risk factors, lifestyle risk factors, and uncontrollable risk factors. Some examples of medical risk factors include high blood pressure, circulation problems, high cholesterol,

Current guidelines state that ezetimibe,is considered the best alternative for LDL reduction and tolerability in statin-intolerant patients and considered an adjuvant in this trial. The primary end point was percentage change from baseline to week 12 in LDL cholesterol. Other end points included measures of safety and tolerability of different doses of AMG145 and AMG145 plus ezetimibe. Other objectives included assessment of the safety and tolerability of 3 different doses of AMG145 and AMG145 plus ezetimibe compared with placebo plus ezetimibe. One hundred sixty patients were randomized into 5 groups, to take AMG 145 as monotherapy once a month at 280mg, 320mg and 420mg, to take AMG 145 420mg once a month with ezetimibe 10mg daily or placebo once a month with ezetimibe 10mg daily. At week 12 the AMG 145 groups had a percent change of blood levels of LDL from baseline from -40.8 % to -50.7 % dose ascending monotherapy and -63.0% with combination with ezetimibe versus -14.8% with combination of placebo and ezetimibe. Reduction in total cholesterol percentwise was from -29.8 % to -37.7 % dose ascending monotherapy and -43.3% with combination with ezetimibe versus -10.7% with combination of placebo and ezetimibe. The overall incidence of all adverse effects was similar among patients receiving

The examples of drugs in this class are atorvastatin (Lipitor), rosuvastatin (Crestor), and simvastatin (Zocor). Statins is the first line to use for lowing blood cholesterol levels. Statins works by blocking the enzyme called HMG-CoA reductase in the liver which is necessary for making cholesterol. The statins blocks the active site of the HMG-CoA reductase enzyme so that it cannot converse to mevalonate. Therefore, there is more LDL receptor available in the liver. These receptors bind to passing LDL and VLDL (very low-density lipoprotein). The LDL and VLDL then enter the liver and are digested. So that there is less LDL level in blood stream. Even though, many drugs are in the same class, but the effectiveness of each drug is different. For example, 5-40 mg of Crestor seems to work best by lowering LDL by 47-65%; whereas 10-40 mg of pravachol can lower LDL by 22-34%. Most people who take statins do not experience serious side effects. The most common minor side effects include headache, pins and needle sensations, abdominal pain, bloating, diarrhea, feeling sick, and a rash. The provider normally starts statins in a low. The dosage may be increased if this target is not reached. Statins are contradicated in patient with active liver disease and consume a large amount of alcohol. The common side effects are GI upset and

Patient has a CVD (cardiovascular disease); can be exacerbated by having high cholesterol (could be the cause of his angina). Therefore, atorvastatin 80 mg was initiated for secondary prevention of CV

Of path the significant pharmaceutical firms don't need persons to grasp they may be able to diminish their ldl cholesterol without statins. They would lose billions of dollars yearly, and that is not what trade is ready. Now, if in case you have excessive ldl cholesterol, you'll close to certainly be reluctant to suppose that whatever so simple as ascorbic acid can effectively diminish your cholesterol. However, I wish to suggest that you simply read all about it on the JBC (Journal of organic Chemistry) internet

Fluvastatin is a highly regarded drug that is involved with treating hypercholesterolemia and preventing cardiovascular disease. The drug is used to lower both high cholesterol and triglycerides levels. The drug is able to perform this task by increasing good cholesterol levels (HDL) while, at the same time, reducing bad cholesterol levels (LDL). Fluvastatin decreases the production of bad cholesterol by blocking the action of the enzyme HMG- CoA reductase in the liver. This results in a decrease in the amount of cholesterol in liver cells and subsequently leads it

Thirteen years ago, cholesterol-lowering drugs called statins were introduced as a treatment for people with heart disease. In the relatively short amount of time the drug has been available, it has been prescribed to nearly five million people. Originally, statins were introduced to prevent heart attacks and prolong the lives of people with existing heart disease or with a history of heart disease. Recently, however, studies have shown that statins are not only useful for the treatment of heart disease, but are also useful in the lowering of cholesterol levels.

INTRODUCTION Cardiovascular disease, currently the leading cause of death and illness in the United States, Europe and most developed countries, is fast growing to become the preeminent health problem worldwide (Murray & Lopez, 1997). Atherosclerosis is a progressive disease of the large and intermediate-sized arteries characterized by accumulation of lipids and fibrous elements which cause development of fatty lesions called atheromatous plaques on the inside surfaces of the arterial walls; and is the single most important contributor to this growing burden of cardiovascular disease. Studies on the pathophysiology of this disease has evolved over the past three decades, and a fusion of these views has led to the concept of the